Fecal corticosterone levels in RCAN1 mutant mice

Tammy Rakowski-Anderson, Helen Wong, Beverly Rothermel, Peter Cain, Carmencita Lavilla, Jennifer K. Pullium, Charles Hoeffer

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Regulator of calcineurin 1 (RCAN1) is related to the expression of human neurologic disorders such as Down syndrome, Alzheimer disease, and chromosome 21q deletion syndrome. We showed here that RCAN1-knockout mice exhibit reduced innate anxiety as indicated by the elevated-plus maze. To examine whether glucocorticoids contribute to this phenotype, we measured fecal corticosterone in male wildtype and RCAN1-knockout mice and in male and female transgenic mice with neuronal overexpression of RCAN1 (Tg-RCAN1TG). We found no difference in fecal corticosterone levels of RCAN1-knockout mice and their wildtype littermates. As expected, we found differences between sexes in fecal corticosterone levels. In addition, we found higher levels of excreted corticosterone in Tg-RCAN1TG female mice as compared with female wildtype mice. Our data indicate normal diurnal corticosterone production in RCAN1 mutant mice and do not suggest a causal role in either the cognitive or anxiety phenotypes exhibited by RCAN1-knockout mice.

Original languageEnglish (US)
Pages (from-to)87-94
Number of pages8
JournalComparative Medicine
Issue number2
StatePublished - Apr 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)


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