Features of urrets-zavalia syndrome after descemet stripping automated endothelial keratoplasty

Didar S. Anwar, Claire Y. Chu, Pawan Prasher, Robert W Bowman, Venkateswara Mootha

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


PURPOSE:: To report a case series of pupil abnormalities consistent with features of Urrets-Zavalia syndrome (UZS) after Descemet stripping automated endothelial keratoplasty (DSAEK) for corneal edema secondary to corneal endothelial cell dysfunction. METHODS:: Retrospective chart analysis of subjects who developed UZS after DSAEK at the University of Texas Southwestern Medical Center. RESULTS:: We present a series of 7 eyes with features consistent with UZS, after undergoing DSAEK. Elevated intraocular pressures (IOP) were noted in the early postoperative period in all cases. Five of 7 had graft dislocation in the postoperative period and required rebubbling or repeat DSAEK to obtain a well-apposed graft. Patients were followed for 3 to 14 months and showed improvement in visual acuity and IOP, but fixed dilated pupils persisted. CONCLUSION:: A fixed irregular or dilated pupil is a rare complication that can be associated with DSAEK surgery. Patients with an elevated IOP and complicated postoperative course seem to be at greater risk for developing iris ischemia and pupil abnormalities consistent with the diagnosis of UZS.

Original languageEnglish (US)
Pages (from-to)1330-1334
Number of pages5
Issue number11
StatePublished - Nov 1 2012


  • Descemet stripping automated endothelial keratoplasty (DSAEK)
  • Urrets-Zavalia syndrome (UZS

ASJC Scopus subject areas

  • Ophthalmology


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