Feasibility of prostate robotic radiation therapy on conventional C-arm linacs

Peng Dong, Dan Nguyen, Dan Ruan, Christopher King, Troy Long, Edwin Romeijn, Daniel A. Low, Patrick Kupelian, Michael Steinberg, Yingli Yang, Ke Sheng

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Purpose: Significant dosimetric improvement for radiation therapy using optimized noncoplanar fields has been previously demonstrated. The purpose here is to study the feasibility of optimized robotic noncoplanar radiation therapy, termed 4π therapy, for prostate cancer treatments on a conventional C-arm linac. Methods and materials: Twelve low-risk prostate cancer patients previously treated by 2-arc volumetric modulated arc therapy (VMAT) were selected. Forty gray in 5 fractions were prescribed to cover 95% of the prostate planning target volume (PTV). To replan by 4π therapy, a column generation method was used to optimize beam orientations and fluence. A total of 30 beams were selected for each patient. Results: Both planning methods provided adequate PTV coverage. Compared against VMAT plans, the 4π plan reduced the rectum V50%, V80%, V90%, D1cc, and the penile bulb maximum doses by 50%, 28%, 19% 11%, and 9% (P < .005), respectively, and the mean body dose was reduced from 2.07 Gy to 1.75 Gy (P = .0001). The bladder dose was only slightly reduced. Conclusions: By optimizing beam angles and fluences in the noncoplanar solution space, superior prostate treatment plan quality was achieved compared against state of the art VMAT plans. The dosimetric potential for 4π therapy is established on an existing C-arm linac platform.

Original languageEnglish (US)
Pages (from-to)254-260
Number of pages7
JournalPractical Radiation Oncology
Issue number4
StatePublished - Jul 2014

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging


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