@inproceedings{5aedaa18b15c4b418601c02824bd1ac9,
title = "Feasibility of MRI-guided focused ultrasound as organ-sparing treatment for testicular cancer",
abstract = "High cure rates for testicular cancer have prompted interest in organ-sparing surgery for patients with bilateral disease or single testis. Focused ultrasound (FUS) ablation could offer a noninvasive approach to organ-sparing surgery. The objective of this study was to determine the feasibility of using MR thermometry to guide organ-sparing focused ultrasound surgery in the testis. The testes of anesthetized rabbits were sonicated in several discrete locations using a single-element focused transducer operating at 2.787MHz. Focal heating was visualized with MR thermometry, using a measured PRF thermal coefficient of -0.0089 ± 0.0003 ppm/°C. Sonications at 3.5-14 acoustic watts applied for 30 seconds produced maximum temperature elevations of 10-80°C, with coagulation verified by histology. Coagulation of precise volumes in the testicle is feasible with MRI-guided focused ultrasound. Variability in peak temperature for given sonication parameters suggests the need for online temperature feedback control.",
keywords = "Focused ultrasound, MRI, Proton resonance frequency shift, Testis, Thermometry",
author = "Robert Staruch and Laura Curiel and Rajiv Chopra and Kullervo Hynynena",
year = "2009",
doi = "10.1063/1.3131398",
language = "English (US)",
isbn = "9780735406506",
series = "AIP Conference Proceedings",
pages = "134--138",
booktitle = "8th International Symposium on Therapeutic Ultrasound",
note = "8th International Symposium on Therapeutic Ultrasound ; Conference date: 10-09-2008 Through 13-09-2008",
}