Feasibility of aortic valve assessment with low dose prospectively triggered adaptive systolic (PTAS) cardiac computed tomography angiography

Ashley M. Lee, Jonathan Beaudoin, Wai Ee Thai, Bryan Wai, Gladwin C. Hui, Manavjot S. Sidhu, Leif Christopher Engel, Suhny Abbara, Udo Hoffmann, Brian B. Ghoshhajra

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: Cardiac computed tomography angiography (CTA) is feasible for aortic valve evaluation, but retrospective gated protocols required high radiation doses for aortic valve assessment. A prospectively triggered adaptive systolic (PTAS) cardiac CT protocol was recently described in arrhythmia using second-generation dual-source CT. In this study, we sought to evaluate the feasibility of PTAS CTA to assess the aortic valve at a low radiation dose. Findings. A retrospective cohort of 29 consecutive patients whom underwent PTAS protocols for clinical indications other than aortic valve assessment and whom also received echocardiography within 2 months of CT, was identified. Images were reviewed for aortic valve morphology (tricuspid/bicuspid/prosthetic) and stenosis (AS) by experienced blinded readers. Accuracy versus echocardiography and radiation doses were assessed.All PTAS coronary CTAs were clinically diagnostic with 0 un-evaluable coronary segments. The accuracy of PTAS for aortic valve morphology was 92.6%, and for exclusion of severe AS was 93.1%. Two exams were un-evaluable for the aortic valve due to inadequate number of phases archived for interpretation. Total radiation dose was a median of 2.8 mSv (interquartile range 1.4-4.4 mSv). Conclusions: PTAS CTA protocols using second-generation dual-source CT for aortic valve evaluation are feasible at low doses. This protocol should be investigated further in larger cohorts.

Original languageEnglish (US)
Article number158
JournalBMC Research Notes
Issue number1
StatePublished - 2013


  • Aortic stenosis
  • Computed tomography angiography
  • Low dose

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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