Abstract
The transformation of follicular lymphoma (FL) to high-grade histology occurs in up to 70% of FL patients. Studies reporting outcomes of transformed FL patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are scant. Eight FL patients with histologically confirmed transformation to diffuse large B-cell lymphoma underwent HSCT at our institution. The median age was 56 years (range 44-63 years). Median follow-up is 60 months. Progression free survival and overall survival at 4-years for patients undergoing allogeneic HSCT is 56% and 66%, respectively. Four patients developed grade II-IV acute GVHD, whereas four patients had extensive chronic GVHD. Day 100 and overall non-relapse mortality rate was 12.5% and 25%, respectively. Allogeneic HSCT appears feasible in patients with transformed FL and is associated with acceptable treatment-related mortality and low relapse rates.
Original language | English (US) |
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Pages (from-to) | 1893-1898 |
Number of pages | 6 |
Journal | Leukemia and Lymphoma |
Volume | 49 |
Issue number | 10 |
DOIs | |
State | Published - 2008 |
Externally published | Yes |
Keywords
- Diffuse large B-cell lymphoma
- GVHD
- Transformed follicular lymphoma
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research