Feasibility of allogeneic hematopoietic stem cell transplantation for follicular lymphoma undergoing transformation to diffuse large B-cell lymphoma

Mehdi Hamadani; Farrukh T. Awan; Patrick Elder; Thomas S. Lin; Pierluigi Porcu; Don M. Benson; Kristie A. Blum; Steven S. Devine

doi:10.1080/10428190802270902

Feasibility of allogeneic hematopoietic stem cell transplantation for follicular lymphoma undergoing transformation to diffuse large B-cell lymphoma

Mehdi Hamadani, Farrukh T. Awan, Patrick Elder, Thomas S. Lin, Pierluigi Porcu, Don M. Benson, Kristie A. Blum, Steven S. Devine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The transformation of follicular lymphoma (FL) to high-grade histology occurs in up to 70% of FL patients. Studies reporting outcomes of transformed FL patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are scant. Eight FL patients with histologically confirmed transformation to diffuse large B-cell lymphoma underwent HSCT at our institution. The median age was 56 years (range 44-63 years). Median follow-up is 60 months. Progression free survival and overall survival at 4-years for patients undergoing allogeneic HSCT is 56% and 66%, respectively. Four patients developed grade II-IV acute GVHD, whereas four patients had extensive chronic GVHD. Day 100 and overall non-relapse mortality rate was 12.5% and 25%, respectively. Allogeneic HSCT appears feasible in patients with transformed FL and is associated with acceptable treatment-related mortality and low relapse rates.

Original language	English (US)
Pages (from-to)	1893-1898
Number of pages	6
Journal	Leukemia and Lymphoma
Volume	49
Issue number	10
DOIs	https://doi.org/10.1080/10428190802270902
State	Published - 2008
Externally published	Yes

Keywords

Diffuse large B-cell lymphoma
GVHD
Transformed follicular lymphoma

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1080/10428190802270902

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title = "Feasibility of allogeneic hematopoietic stem cell transplantation for follicular lymphoma undergoing transformation to diffuse large B-cell lymphoma",

abstract = "The transformation of follicular lymphoma (FL) to high-grade histology occurs in up to 70% of FL patients. Studies reporting outcomes of transformed FL patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are scant. Eight FL patients with histologically confirmed transformation to diffuse large B-cell lymphoma underwent HSCT at our institution. The median age was 56 years (range 44-63 years). Median follow-up is 60 months. Progression free survival and overall survival at 4-years for patients undergoing allogeneic HSCT is 56% and 66%, respectively. Four patients developed grade II-IV acute GVHD, whereas four patients had extensive chronic GVHD. Day 100 and overall non-relapse mortality rate was 12.5% and 25%, respectively. Allogeneic HSCT appears feasible in patients with transformed FL and is associated with acceptable treatment-related mortality and low relapse rates.",

keywords = "Diffuse large B-cell lymphoma, GVHD, Transformed follicular lymphoma",

author = "Mehdi Hamadani and Awan, {Farrukh T.} and Patrick Elder and Lin, {Thomas S.} and Pierluigi Porcu and Benson, {Don M.} and Blum, {Kristie A.} and Devine, {Steven S.}",

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AU - Hamadani, Mehdi

AU - Awan, Farrukh T.

AU - Elder, Patrick

AU - Lin, Thomas S.

AU - Porcu, Pierluigi

AU - Benson, Don M.

AU - Blum, Kristie A.

AU - Devine, Steven S.

PY - 2008

Y1 - 2008

N2 - The transformation of follicular lymphoma (FL) to high-grade histology occurs in up to 70% of FL patients. Studies reporting outcomes of transformed FL patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are scant. Eight FL patients with histologically confirmed transformation to diffuse large B-cell lymphoma underwent HSCT at our institution. The median age was 56 years (range 44-63 years). Median follow-up is 60 months. Progression free survival and overall survival at 4-years for patients undergoing allogeneic HSCT is 56% and 66%, respectively. Four patients developed grade II-IV acute GVHD, whereas four patients had extensive chronic GVHD. Day 100 and overall non-relapse mortality rate was 12.5% and 25%, respectively. Allogeneic HSCT appears feasible in patients with transformed FL and is associated with acceptable treatment-related mortality and low relapse rates.

AB - The transformation of follicular lymphoma (FL) to high-grade histology occurs in up to 70% of FL patients. Studies reporting outcomes of transformed FL patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are scant. Eight FL patients with histologically confirmed transformation to diffuse large B-cell lymphoma underwent HSCT at our institution. The median age was 56 years (range 44-63 years). Median follow-up is 60 months. Progression free survival and overall survival at 4-years for patients undergoing allogeneic HSCT is 56% and 66%, respectively. Four patients developed grade II-IV acute GVHD, whereas four patients had extensive chronic GVHD. Day 100 and overall non-relapse mortality rate was 12.5% and 25%, respectively. Allogeneic HSCT appears feasible in patients with transformed FL and is associated with acceptable treatment-related mortality and low relapse rates.

KW - Diffuse large B-cell lymphoma

KW - GVHD

KW - Transformed follicular lymphoma

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Feasibility of allogeneic hematopoietic stem cell transplantation for follicular lymphoma undergoing transformation to diffuse large B-cell lymphoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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