Abstract
The contribution of the extracellular matrix (ECM) to the microenvironment of solid tumors is appreciated although not completely understood; however, the contribution of the ECM to the development of hematopoietic tumors has not been investigated in depth. A new study by Sangaletti and colleagues demonstrates that faulty ECM signaling can facilitate malignant lymphoproliferation in mice predisposed to autoimmunity. Similar changes in ECM construction, consistent with a loss of inhibitory ECM signaling, were identifi ed in the transition from reactive lymphoid hyperplasia to malignant chronic lymphocytic leukemia in patients. These results reveal a critical contribution of reduced collagen signaling in lymphoma and highlight the importance of appropriate ECM construction for maintenance of tissue homeostasis.
Original language | English (US) |
---|---|
Pages (from-to) | 25-26 |
Number of pages | 2 |
Journal | Cancer discovery |
Volume | 4 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2014 |
ASJC Scopus subject areas
- Oncology