Fatal hemolysis induced by ceftriaxone in a child with sickle cell anemia

Juan C. Bernini; Mahmoud M. Mustafa; Laurie J. Sutor; George R. Buchanan

doi:10.1016/S0022-3476(95)70417-5

Fatal hemolysis induced by ceftriaxone in a child with sickle cell anemia

Juan C. Bernini, Mahmoud M. Mustafa, Laurie J. Sutor, George R. Buchanan

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Abstract

A 2-year-old boy with sickle cell anemia had a massive, fatal hemolytic reaction after administration of an intravenous dose of ceftriaxone. Laboratory studies demonstrated the presence of an IgM antibody against ceftriaxone, binding to and destroying the patient's erythrocytes by an immune complex mechanism. This rare complication should be considered in the differential diagnosis when hemoglobinuria develops in a child after administration of ceftriaxone or a similar agent. (J P EDIATR 1995;126:813-5).

Original language	English (US)
Pages (from-to)	813-815
Number of pages	3
Journal	The Journal of pediatrics
Volume	126
Issue number	5
DOIs	https://doi.org/10.1016/S0022-3476(95)70417-5
State	Published - May 1995

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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title = "Fatal hemolysis induced by ceftriaxone in a child with sickle cell anemia",

abstract = "A 2-year-old boy with sickle cell anemia had a massive, fatal hemolytic reaction after administration of an intravenous dose of ceftriaxone. Laboratory studies demonstrated the presence of an IgM antibody against ceftriaxone, binding to and destroying the patient's erythrocytes by an immune complex mechanism. This rare complication should be considered in the differential diagnosis when hemoglobinuria develops in a child after administration of ceftriaxone or a similar agent. (J P EDIATR 1995;126:813-5).",

author = "Bernini, {Juan C.} and Mustafa, {Mahmoud M.} and Sutor, {Laurie J.} and Buchanan, {George R.}",

note = "Funding Information: Supported in part by Children's Cancer Fund of Dallas and Consejo Nacional para Investigaciones Cient{\'i}ficas y Tecnologicas, San Jos{\'e}, Costa Rica. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1995",

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AU - Bernini, Juan C.

AU - Mustafa, Mahmoud M.

AU - Sutor, Laurie J.

AU - Buchanan, George R.

N1 - Funding Information: Supported in part by Children's Cancer Fund of Dallas and Consejo Nacional para Investigaciones Científicas y Tecnologicas, San José, Costa Rica. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1995/5

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N2 - A 2-year-old boy with sickle cell anemia had a massive, fatal hemolytic reaction after administration of an intravenous dose of ceftriaxone. Laboratory studies demonstrated the presence of an IgM antibody against ceftriaxone, binding to and destroying the patient's erythrocytes by an immune complex mechanism. This rare complication should be considered in the differential diagnosis when hemoglobinuria develops in a child after administration of ceftriaxone or a similar agent. (J P EDIATR 1995;126:813-5).

AB - A 2-year-old boy with sickle cell anemia had a massive, fatal hemolytic reaction after administration of an intravenous dose of ceftriaxone. Laboratory studies demonstrated the presence of an IgM antibody against ceftriaxone, binding to and destroying the patient's erythrocytes by an immune complex mechanism. This rare complication should be considered in the differential diagnosis when hemoglobinuria develops in a child after administration of ceftriaxone or a similar agent. (J P EDIATR 1995;126:813-5).

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Fatal hemolysis induced by ceftriaxone in a child with sickle cell anemia

Abstract

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