Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis

Benjamin M. Greenberg; Theron Charles Casper; Soe S. Mar; Jayne M. Ness; Patricia Plumb; Shannon Liang; Manu Goyal; Bianca Weinstock-Guttman; Moses Rodriguez; Gregory S. Aaen; Anita Belman; Lisa F. Barcellos; John W. Rose; Mark P. Gorman; Leslie A. Benson; Meghan Candee; Tanuja Chitnis; Yolanda C. Harris; Ilana L. Kahn; Shelly Roalstad; Janace Hart; Timothy E. Lotze; Mary Rensel; Jennifer P. Rubin; Teri L. Schreiner; Jan Mendelt Tillema; Amy Tara Waldman; Lauren Krupp; Jennifer Graves; Kaylea Drake; Emmanuelle Waubant

doi:10.1212/NXI.0000000000001049

Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis

Benjamin M. Greenberg, Theron Charles Casper, Soe S. Mar, Jayne M. Ness, Patricia Plumb, Shannon Liang, Manu Goyal, Bianca Weinstock-Guttman, Moses Rodriguez, Gregory S. Aaen, Anita Belman, Lisa F. Barcellos, John W. Rose, Mark P. Gorman, Leslie A. Benson, Meghan Candee, Tanuja Chitnis, Yolanda C. Harris, Ilana L. Kahn, Shelly RoalstadJanace Hart, Timothy E. Lotze, Mary Rensel, Jennifer P. Rubin, Teri L. Schreiner, Jan Mendelt Tillema, Amy Tara Waldman, Lauren Krupp, Jennifer Graves, Kaylea Drake, Emmanuelle Waubant

Research output: Contribution to journal › Article › peer-review

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Abstract

Background and Objective: The objective of this study was to determine whether family members of patients with pediatric multiple sclerosis (MS) have an increased prevalence of autoimmune conditions compared with controls. Methods: Data collected during a pediatric MS case-control study of risk factors included information about various autoimmune diseases in family members. The frequency of these disorders was compared between cases and controls. Results: There was an increased rate of autoimmune diseases among family members of pediatric MS cases compared with controls with first-degree history of MS excluded (OR = 2.27, 95% CI 1.71-3.01, p < 0.001). There was an increased rate of MS among second-degree relatives of pediatric MS cases compared with controls (OR = 3.47, 95% CI 1.36-8.86, p = 0.009). The OR for MS was 2.64 when restricted to maternal relatives and 6.37 when restricted to paternal relatives. Discussion: The increased rates of autoimmune disorders, including thyroid disorders and MS among families of patients with pediatric MS, suggest shared genetic factors among families with children diagnosed with pediatric MS.

Original language	English (US)
Article number	e1049
Journal	Neurology: Neuroimmunology and NeuroInflammation
Volume	8
Issue number	5
DOIs	https://doi.org/10.1212/NXI.0000000000001049
State	Published - Sep 5 2021

ASJC Scopus subject areas

Clinical Neurology
Neurology

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Greenberg, B. M., Casper, T. C., Mar, S. S., Ness, J. M., Plumb, P., Liang, S., Goyal, M., Weinstock-Guttman, B., Rodriguez, M., Aaen, G. S., Belman, A., Barcellos, L. F., Rose, J. W., Gorman, M. P., Benson, L. A., Candee, M., Chitnis, T., Harris, Y. C., Kahn, I. L., ... Waubant, E. (2021). Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis. Neurology: Neuroimmunology and NeuroInflammation, 8(5), Article e1049. https://doi.org/10.1212/NXI.0000000000001049

Greenberg, BM, Casper, TC, Mar, SS, Ness, JM, Plumb, P, Liang, S, Goyal, M, Weinstock-Guttman, B, Rodriguez, M, Aaen, GS, Belman, A, Barcellos, LF, Rose, JW, Gorman, MP, Benson, LA, Candee, M, Chitnis, T, Harris, YC, Kahn, IL, Roalstad, S, Hart, J, Lotze, TE, Rensel, M, Rubin, JP, Schreiner, TL, Tillema, JM, Waldman, AT, Krupp, L, Graves, J, Drake, K & Waubant, E 2021, 'Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis', Neurology: Neuroimmunology and NeuroInflammation, vol. 8, no. 5, e1049. https://doi.org/10.1212/NXI.0000000000001049

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title = "Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis",

abstract = "Background and Objective: The objective of this study was to determine whether family members of patients with pediatric multiple sclerosis (MS) have an increased prevalence of autoimmune conditions compared with controls. Methods: Data collected during a pediatric MS case-control study of risk factors included information about various autoimmune diseases in family members. The frequency of these disorders was compared between cases and controls. Results: There was an increased rate of autoimmune diseases among family members of pediatric MS cases compared with controls with first-degree history of MS excluded (OR = 2.27, 95% CI 1.71-3.01, p < 0.001). There was an increased rate of MS among second-degree relatives of pediatric MS cases compared with controls (OR = 3.47, 95% CI 1.36-8.86, p = 0.009). The OR for MS was 2.64 when restricted to maternal relatives and 6.37 when restricted to paternal relatives. Discussion: The increased rates of autoimmune disorders, including thyroid disorders and MS among families of patients with pediatric MS, suggest shared genetic factors among families with children diagnosed with pediatric MS.",

author = "Greenberg, {Benjamin M.} and Casper, {Theron Charles} and Mar, {Soe S.} and Ness, {Jayne M.} and Patricia Plumb and Shannon Liang and Manu Goyal and Bianca Weinstock-Guttman and Moses Rodriguez and Aaen, {Gregory S.} and Anita Belman and Barcellos, {Lisa F.} and Rose, {John W.} and Gorman, {Mark P.} and Benson, {Leslie A.} and Meghan Candee and Tanuja Chitnis and Harris, {Yolanda C.} and Kahn, {Ilana L.} and Shelly Roalstad and Janace Hart and Lotze, {Timothy E.} and Mary Rensel and Rubin, {Jennifer P.} and Schreiner, {Teri L.} and Tillema, {Jan Mendelt} and Waldman, {Amy Tara} and Lauren Krupp and Jennifer Graves and Kaylea Drake and Emmanuelle Waubant",

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year = "2021",

month = sep,

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doi = "10.1212/NXI.0000000000001049",

language = "English (US)",

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T1 - Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis

AU - Greenberg, Benjamin M.

AU - Casper, Theron Charles

AU - Mar, Soe S.

AU - Ness, Jayne M.

AU - Plumb, Patricia

AU - Liang, Shannon

AU - Goyal, Manu

AU - Weinstock-Guttman, Bianca

AU - Rodriguez, Moses

AU - Aaen, Gregory S.

AU - Belman, Anita

AU - Barcellos, Lisa F.

AU - Rose, John W.

AU - Gorman, Mark P.

AU - Benson, Leslie A.

AU - Candee, Meghan

AU - Chitnis, Tanuja

AU - Harris, Yolanda C.

AU - Kahn, Ilana L.

AU - Roalstad, Shelly

AU - Hart, Janace

AU - Lotze, Timothy E.

AU - Rensel, Mary

AU - Rubin, Jennifer P.

AU - Schreiner, Teri L.

AU - Tillema, Jan Mendelt

AU - Waldman, Amy Tara

AU - Krupp, Lauren

AU - Graves, Jennifer

AU - Drake, Kaylea

AU - Waubant, Emmanuelle

PY - 2021/9/5

Y1 - 2021/9/5

N2 - Background and Objective: The objective of this study was to determine whether family members of patients with pediatric multiple sclerosis (MS) have an increased prevalence of autoimmune conditions compared with controls. Methods: Data collected during a pediatric MS case-control study of risk factors included information about various autoimmune diseases in family members. The frequency of these disorders was compared between cases and controls. Results: There was an increased rate of autoimmune diseases among family members of pediatric MS cases compared with controls with first-degree history of MS excluded (OR = 2.27, 95% CI 1.71-3.01, p < 0.001). There was an increased rate of MS among second-degree relatives of pediatric MS cases compared with controls (OR = 3.47, 95% CI 1.36-8.86, p = 0.009). The OR for MS was 2.64 when restricted to maternal relatives and 6.37 when restricted to paternal relatives. Discussion: The increased rates of autoimmune disorders, including thyroid disorders and MS among families of patients with pediatric MS, suggest shared genetic factors among families with children diagnosed with pediatric MS.

AB - Background and Objective: The objective of this study was to determine whether family members of patients with pediatric multiple sclerosis (MS) have an increased prevalence of autoimmune conditions compared with controls. Methods: Data collected during a pediatric MS case-control study of risk factors included information about various autoimmune diseases in family members. The frequency of these disorders was compared between cases and controls. Results: There was an increased rate of autoimmune diseases among family members of pediatric MS cases compared with controls with first-degree history of MS excluded (OR = 2.27, 95% CI 1.71-3.01, p < 0.001). There was an increased rate of MS among second-degree relatives of pediatric MS cases compared with controls (OR = 3.47, 95% CI 1.36-8.86, p = 0.009). The OR for MS was 2.64 when restricted to maternal relatives and 6.37 when restricted to paternal relatives. Discussion: The increased rates of autoimmune disorders, including thyroid disorders and MS among families of patients with pediatric MS, suggest shared genetic factors among families with children diagnosed with pediatric MS.

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Familial History of Autoimmune Disorders Among Patients With Pediatric Multiple Sclerosis

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