Familial Barrett Esophagus and Adenocarcinoma of the Gastroesophageal Junction

Charis Eng, Stuart Jon Spechler, Robert Ruben, Frederick P. Li

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Barrett esophagus was found in seven members of a single family. Two of these patients also had adenocarcinoma of the gastroesophageal junction. Among family members who did not have Barrett epithelium, one had esophageal ulcerations with dysplasia in squamous epithelium and another had an esophageal stricture. The pattern of involvement suggests autosomal dominant inheritance of Barrett esophagus and/or gastroesophageal reflux disease in this family, with a strong predisposition for adenocarcinoma of the esophagus.

Original languageEnglish (US)
Pages (from-to)397-399
Number of pages3
JournalCancer Epidemiology Biomarkers and Prevention
Issue number4
StatePublished - Jul 1 1993

ASJC Scopus subject areas

  • Epidemiology
  • Oncology


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