Factors associated with African Americans' enrollment in a national cancer genetics registry

C. S. Skinner, J. M. Schildkraut, B. Calingaert, C. Hoyo, S. S. Crankshaw, L. Fish, L. Susswein, C. Jasper, L. Reid

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


This study explored whether reactions to the Cancer Genetics Network (CGN) or CGN enrollment differed by receipt of a standard informational brochure versus a targeted version addressing factors previously associated with African Americans' health behavior decisions and research participation. The 262 participants, identified through tumor registries or clinic contacts, were mailed brochures and completed phone interviews. When asked whether - based on the brochure - they were or were not 'leaning toward' CGN enrollment, about 75% of both standard and targeted groups reported leaning toward. When given the opportunity at the end of the interview, 68% enrolled in the CGN. Trust was strongly related to enrollment. Less education, less satisfaction with cancer care, and individualistic rather than collective orientation were associated with lower trust. Education was also bivariately associated with enrollment, but mediation analysis indicated that the operational mechanism of education's influence on enrollment was through trust.

Original languageEnglish (US)
Pages (from-to)224-233
Number of pages10
JournalCommunity Genetics
Issue number4
StatePublished - Apr 1 2008


  • African Americans
  • Cancer Genetics Network
  • Cancer genetics registry

ASJC Scopus subject areas

  • Genetics(clinical)


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