TY - JOUR
T1 - F-18 FDG PET/CT characterization of talc pleurodesis-induced pleural changes over time
T2 - A retrospective study
AU - Nguyen, Nghi C.
AU - Tran, Isaac
AU - Hueser, Christopher N.
AU - Oliver, Dana
AU - Farghaly, Hussein R.
AU - Osman, Medhat M.
PY - 2009/12
Y1 - 2009/12
N2 - Purpose: The current study characterized pleural changes induced by talc pleurodesis (TP), based on serial positron emission tomography/computer- tomography (PET/CT) with F-18 fluorodeoxyglucose (FDG). Materials and Methods: A total of 8 cancer patients who had both TP and PET/CT and no evidence of active pleural involvement after TP were retrospectively evaluatedMaximum standard uptake values, maximum Hounsfield units (HU), and thickness were followed over time. Results: The 8 patients had 25 PET/CT scans performed in an average of 22 months after TPAn increased FDG uptake was associated with an increase in pleural thickness within 5 months after TP, and both parameters showed statistical significance as compared with findings before TPAfter 5 months of TP, the standard uptake value appeared to persist or increase further, and the pleural thickening stabilizedThe formation of calcification was a slow process and might lag behind the changes in FDG metabolism and pleural thicknessThe HU did not change significantly once pleural calcification had been formed. Conclusions: Knowledge of aforementioned pleural changes may help differentiate TP induced pleural inflammation from pleural malignancy and to avoid false-positive interpretation of FDG PET/CT exams.
AB - Purpose: The current study characterized pleural changes induced by talc pleurodesis (TP), based on serial positron emission tomography/computer- tomography (PET/CT) with F-18 fluorodeoxyglucose (FDG). Materials and Methods: A total of 8 cancer patients who had both TP and PET/CT and no evidence of active pleural involvement after TP were retrospectively evaluatedMaximum standard uptake values, maximum Hounsfield units (HU), and thickness were followed over time. Results: The 8 patients had 25 PET/CT scans performed in an average of 22 months after TPAn increased FDG uptake was associated with an increase in pleural thickness within 5 months after TP, and both parameters showed statistical significance as compared with findings before TPAfter 5 months of TP, the standard uptake value appeared to persist or increase further, and the pleural thickening stabilizedThe formation of calcification was a slow process and might lag behind the changes in FDG metabolism and pleural thicknessThe HU did not change significantly once pleural calcification had been formed. Conclusions: Knowledge of aforementioned pleural changes may help differentiate TP induced pleural inflammation from pleural malignancy and to avoid false-positive interpretation of FDG PET/CT exams.
KW - F-18 FDG PET/CT
KW - Pleural changes
KW - Talc pleurodesis
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U2 - 10.1097/RLU.0b013e3181bece11
DO - 10.1097/RLU.0b013e3181bece11
M3 - Article
C2 - 20139823
AN - SCOPUS:74249088962
SN - 0363-9762
VL - 34
SP - 886
EP - 890
JO - Clinical nuclear medicine
JF - Clinical nuclear medicine
IS - 12
ER -