F-18 FDG PET/CT characterization of talc pleurodesis-induced pleural changes over time: A retrospective study

Nghi C. Nguyen, Isaac Tran, Christopher N. Hueser, Dana Oliver, Hussein R. Farghaly, Medhat M. Osman

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Purpose: The current study characterized pleural changes induced by talc pleurodesis (TP), based on serial positron emission tomography/computer- tomography (PET/CT) with F-18 fluorodeoxyglucose (FDG). Materials and Methods: A total of 8 cancer patients who had both TP and PET/CT and no evidence of active pleural involvement after TP were retrospectively evaluatedMaximum standard uptake values, maximum Hounsfield units (HU), and thickness were followed over time. Results: The 8 patients had 25 PET/CT scans performed in an average of 22 months after TPAn increased FDG uptake was associated with an increase in pleural thickness within 5 months after TP, and both parameters showed statistical significance as compared with findings before TPAfter 5 months of TP, the standard uptake value appeared to persist or increase further, and the pleural thickening stabilizedThe formation of calcification was a slow process and might lag behind the changes in FDG metabolism and pleural thicknessThe HU did not change significantly once pleural calcification had been formed. Conclusions: Knowledge of aforementioned pleural changes may help differentiate TP induced pleural inflammation from pleural malignancy and to avoid false-positive interpretation of FDG PET/CT exams.

Original languageEnglish (US)
Pages (from-to)886-890
Number of pages5
JournalClinical nuclear medicine
Issue number12
StatePublished - Dec 2009
Externally publishedYes


  • F-18 FDG PET/CT
  • Pleural changes
  • Talc pleurodesis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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