Eye Tracking and Mental Illness

D. L. Levy, J. A. Sweeney

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Eye-tracking abnormalities are one of the most promising endophenotypes for schizophrenia. Eye-tracking dysfunction (ETD) involves a primary disturbance in the smooth pursuit system and a secondary disturbance involving saccadic disinhibition. Eye tracking has high heritability. Linkage has been reported between ETD and loci on chromosome 6p. Recurrence risk for ETD in first-degree relatives of schizophrenics is much higher than that of schizophrenia, suggesting that ETD may be a more penetrant pleiotropic expression of gene(s) that increase the risk for schizophrenia and may therefore have greater power to identify schizophrenia-susceptibility genes than the clinical phenotype alone.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages6
ISBN (Print)9780080450469
StatePublished - 2009


  • Affective disorders
  • Endophenotypes
  • Frontal eye fields
  • Medial superior temporal area
  • Middle temporal visual area
  • Motion processing
  • Pleiotropy
  • Posterior parietal cortex
  • Schizophrenia
  • Smooth pursuit eye movements

ASJC Scopus subject areas

  • General Neuroscience


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