Eye gaze and pupillary response in Angelman syndrome

Michael P. Hong, Janna L. Guilfoyle, Lindsey N. Mooney, Logan K. Wink, Ernest V. Pedapati, Rebecca C. Shaffer, John A. Sweeney, Craig A. Erickson

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Background Angelman syndrome (AS) is a rare neurological disorder characterized by severe developmental disability, communication impairment, elevated seizure risk, and motor system abnormalities. Aims The aims of this study were to determine the feasibility of social scene eye tracking and pupillometry measures in individuals with AS and to compare the performance of AS participants to individuals with idiopathic Autism Spectrum Disorder (ASD) and typically developing controls (TDC). Methods and procedures Individuals with AS and age- and gender- matched controls completed a social eye tracking paradigm. Neurobehavioral characterization of AS participants was completed via a battery of psychological testing and caregiver behavioral evaluations. Outcomes and results Eight of seventeen recruited AS participants completed the eye tracking paradigm. Compared to TDC, AS subjects demonstrated significantly less preference for social scenes than geometric shapes. Additionally, AS subjects showed less pupil dilation, compared to TDC, when viewing social scenes versus geometric shapes. There was no statistically significant difference found between AS and ASD subjects in either social eye tracking or pupillometry. Conclusions and implications The use of eye tracking and pupillometry may represent an innovative measure for quantifying AS-associated impairments in social salience.

Original languageEnglish (US)
Pages (from-to)88-94
Number of pages7
JournalResearch in Developmental Disabilities
StatePublished - Sep 2017


  • Angelman syndrome
  • Developmental disabilities
  • Eye tracking
  • Pupillometry

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology


Dive into the research topics of 'Eye gaze and pupillary response in Angelman syndrome'. Together they form a unique fingerprint.

Cite this