Extrapulmonary small cell sarcinoma: Involvement of the brain without evidence of extracranial malignancy by serial PET/CT scans

Christopher N. Hueser; Nghi C. Nguyen; Medhat Osman; Necat Havlioglu; Anjali J. Patel

doi:10.1186/1477-7819-6-102

Extrapulmonary small cell sarcinoma: Involvement of the brain without evidence of extracranial malignancy by serial PET/CT scans

Christopher N. Hueser, Nghi C. Nguyen, Medhat Osman, Necat Havlioglu, Anjali J. Patel

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7 Scopus citations

Abstract

Background: Extrapulmonary small cell carcinoma (EPSCC) involving the brain is a rare manifestation of an uncommon tumor type. Case presentation: We report a 59 year-old Caucasian female diagnosed with an EPSCC involving the left parietal lobe without detectable extracranial primary tumor followed by serial positron emission tomography/computed tomography (PET/CT) imaging. Histopathological examination at both initial presentation and recurrence revealed small cell carcinoma. Serial PET/CT scans of the entire body failed to reveal any extracranial [18F]2-fluoro-2-deoxy-D-glucose (FDG) avid lesions at either diagnosis or follow-up. Conclusion: Chemotherapy may show a transient response in the treatment of EPSCC. Further studies are needed to help identify optimal treatment strategies. Combination PET/CT technology may be a useful tool to monitor EPSCC and assess for an occult primary malignancy.

Original language	English (US)
Article number	102
Journal	World Journal of Surgical Oncology
Volume	6
DOIs	https://doi.org/10.1186/1477-7819-6-102
State	Published - Sep 25 2008
Externally published	Yes

ASJC Scopus subject areas

Surgery
Oncology

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10.1186/1477-7819-6-102

Cite this

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title = "Extrapulmonary small cell sarcinoma: Involvement of the brain without evidence of extracranial malignancy by serial PET/CT scans",

abstract = "Background: Extrapulmonary small cell carcinoma (EPSCC) involving the brain is a rare manifestation of an uncommon tumor type. Case presentation: We report a 59 year-old Caucasian female diagnosed with an EPSCC involving the left parietal lobe without detectable extracranial primary tumor followed by serial positron emission tomography/computed tomography (PET/CT) imaging. Histopathological examination at both initial presentation and recurrence revealed small cell carcinoma. Serial PET/CT scans of the entire body failed to reveal any extracranial [18F]2-fluoro-2-deoxy-D-glucose (FDG) avid lesions at either diagnosis or follow-up. Conclusion: Chemotherapy may show a transient response in the treatment of EPSCC. Further studies are needed to help identify optimal treatment strategies. Combination PET/CT technology may be a useful tool to monitor EPSCC and assess for an occult primary malignancy.",

author = "Hueser, {Christopher N.} and Nguyen, {Nghi C.} and Medhat Osman and Necat Havlioglu and Patel, {Anjali J.}",

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journal = "World Journal of Surgical Oncology",

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TY - JOUR

T1 - Extrapulmonary small cell sarcinoma

T2 - Involvement of the brain without evidence of extracranial malignancy by serial PET/CT scans

AU - Hueser, Christopher N.

AU - Nguyen, Nghi C.

AU - Osman, Medhat

AU - Havlioglu, Necat

AU - Patel, Anjali J.

PY - 2008/9/25

Y1 - 2008/9/25

N2 - Background: Extrapulmonary small cell carcinoma (EPSCC) involving the brain is a rare manifestation of an uncommon tumor type. Case presentation: We report a 59 year-old Caucasian female diagnosed with an EPSCC involving the left parietal lobe without detectable extracranial primary tumor followed by serial positron emission tomography/computed tomography (PET/CT) imaging. Histopathological examination at both initial presentation and recurrence revealed small cell carcinoma. Serial PET/CT scans of the entire body failed to reveal any extracranial [18F]2-fluoro-2-deoxy-D-glucose (FDG) avid lesions at either diagnosis or follow-up. Conclusion: Chemotherapy may show a transient response in the treatment of EPSCC. Further studies are needed to help identify optimal treatment strategies. Combination PET/CT technology may be a useful tool to monitor EPSCC and assess for an occult primary malignancy.

AB - Background: Extrapulmonary small cell carcinoma (EPSCC) involving the brain is a rare manifestation of an uncommon tumor type. Case presentation: We report a 59 year-old Caucasian female diagnosed with an EPSCC involving the left parietal lobe without detectable extracranial primary tumor followed by serial positron emission tomography/computed tomography (PET/CT) imaging. Histopathological examination at both initial presentation and recurrence revealed small cell carcinoma. Serial PET/CT scans of the entire body failed to reveal any extracranial [18F]2-fluoro-2-deoxy-D-glucose (FDG) avid lesions at either diagnosis or follow-up. Conclusion: Chemotherapy may show a transient response in the treatment of EPSCC. Further studies are needed to help identify optimal treatment strategies. Combination PET/CT technology may be a useful tool to monitor EPSCC and assess for an occult primary malignancy.

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Extrapulmonary small cell sarcinoma: Involvement of the brain without evidence of extracranial malignancy by serial PET/CT scans

Abstract

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