Expression of carcinoembryonic antigen in ulcerative colitis, tubular adenomas and hyperplastic polyps: Correlations with the degree of dysplasia

Z. P. Pavelic; L. Pavelic; K. Pavelic; R. M. Genta; M. B. Ray; G. Dvornik; M. Scukanec-Spoljar; J. S. Peacock

Expression of carcinoembryonic antigen in ulcerative colitis, tubular adenomas and hyperplastic polyps: Correlations with the degree of dysplasia

Z. P. Pavelic, L. Pavelic, K. Pavelic, R. M. Genta, M. B. Ray, G. Dvornik, M. Scukanec-Spoljar, J. S. Peacock

Research output: Contribution to journal › Article › peer-review

Abstract

Sections of tubular adenomas (n=40), ulcertive colitis (n=97) and hyperplastic polyps (n=31) were examined by immunoperoxidase staining to carcinoembryonic antigen (CEA) in order to assess its potential diagnostic value in predicting malignant potential of these lesions. We compared the degree of epithelial abnormality in these mucosal specimens with the extent of immunoperoxidase staining for CEA. We found that CEA staining correlated with the degree of epithelial alteration in tubular adenoma and ulcerative colitis groups. Scatterred weakly positive staining was found in eight of 31 hyperplastic polyps. High tissue expression of CEA, when combined with histologic dysplasia, may prove to be an additional factor in the evaluation of malignant potential in ulcerative colitis specimens and adenomas.

Original language	English (US)
Pages (from-to)	1671-1675
Number of pages	5
Journal	Anticancer Research
Volume	11
Issue number	5
State	Published - 1991

Keywords

Carcinoembryonic antigen
Dysplasia degree
Hyperplastic polyps
Tubular adenoma
Ulcerative colitis

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Expression of carcinoembryonic antigen in ulcerative colitis, tubular adenomas and hyperplastic polyps: Correlations with the degree of dysplasia",

abstract = "Sections of tubular adenomas (n=40), ulcertive colitis (n=97) and hyperplastic polyps (n=31) were examined by immunoperoxidase staining to carcinoembryonic antigen (CEA) in order to assess its potential diagnostic value in predicting malignant potential of these lesions. We compared the degree of epithelial abnormality in these mucosal specimens with the extent of immunoperoxidase staining for CEA. We found that CEA staining correlated with the degree of epithelial alteration in tubular adenoma and ulcerative colitis groups. Scatterred weakly positive staining was found in eight of 31 hyperplastic polyps. High tissue expression of CEA, when combined with histologic dysplasia, may prove to be an additional factor in the evaluation of malignant potential in ulcerative colitis specimens and adenomas.",

keywords = "Carcinoembryonic antigen, Dysplasia degree, Hyperplastic polyps, Tubular adenoma, Ulcerative colitis",

author = "Pavelic, {Z. P.} and L. Pavelic and K. Pavelic and Genta, {R. M.} and Ray, {M. B.} and G. Dvornik and M. Scukanec-Spoljar and Peacock, {J. S.}",

year = "1991",

language = "English (US)",

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T1 - Expression of carcinoembryonic antigen in ulcerative colitis, tubular adenomas and hyperplastic polyps

T2 - Correlations with the degree of dysplasia

AU - Pavelic, Z. P.

AU - Pavelic, L.

AU - Pavelic, K.

AU - Genta, R. M.

AU - Ray, M. B.

AU - Dvornik, G.

AU - Scukanec-Spoljar, M.

AU - Peacock, J. S.

PY - 1991

Y1 - 1991

N2 - Sections of tubular adenomas (n=40), ulcertive colitis (n=97) and hyperplastic polyps (n=31) were examined by immunoperoxidase staining to carcinoembryonic antigen (CEA) in order to assess its potential diagnostic value in predicting malignant potential of these lesions. We compared the degree of epithelial abnormality in these mucosal specimens with the extent of immunoperoxidase staining for CEA. We found that CEA staining correlated with the degree of epithelial alteration in tubular adenoma and ulcerative colitis groups. Scatterred weakly positive staining was found in eight of 31 hyperplastic polyps. High tissue expression of CEA, when combined with histologic dysplasia, may prove to be an additional factor in the evaluation of malignant potential in ulcerative colitis specimens and adenomas.

AB - Sections of tubular adenomas (n=40), ulcertive colitis (n=97) and hyperplastic polyps (n=31) were examined by immunoperoxidase staining to carcinoembryonic antigen (CEA) in order to assess its potential diagnostic value in predicting malignant potential of these lesions. We compared the degree of epithelial abnormality in these mucosal specimens with the extent of immunoperoxidase staining for CEA. We found that CEA staining correlated with the degree of epithelial alteration in tubular adenoma and ulcerative colitis groups. Scatterred weakly positive staining was found in eight of 31 hyperplastic polyps. High tissue expression of CEA, when combined with histologic dysplasia, may prove to be an additional factor in the evaluation of malignant potential in ulcerative colitis specimens and adenomas.

KW - Carcinoembryonic antigen

KW - Dysplasia degree

KW - Hyperplastic polyps

KW - Tubular adenoma

KW - Ulcerative colitis

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AN - SCOPUS:0026326749

SN - 0250-7005

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SP - 1671

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JO - Anticancer Research

JF - Anticancer Research

IS - 5

ER -

Expression of carcinoembryonic antigen in ulcerative colitis, tubular adenomas and hyperplastic polyps: Correlations with the degree of dysplasia

Abstract

Keywords

ASJC Scopus subject areas

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