Expression of bcl-2 in Small Cell Lung Carcinoma Cells

Naohiko Ikegaki, Makoto Katsumata, John Minna, Yoshihide Tsujimoto

Research output: Contribution to journalArticlepeer-review

222 Scopus citations


We have investigated the expression of bcl-2α protein in a panel of small cell lung carcinoma (SCLC) cells lines. Five of six cell lines examined expressed relatively high levels of bcl-2 protein and transcripts. The bcl-2 expression in SCLC cells, however, was not always associated with myc expression. Since dysregulation of bcl-2 may be involved in the course of tumorigenesis and/or in the acquisition of drug resistance of tumor cells, the expression of bcl-2 in SCLC cells may become an important indicator in the prognosis or treatment of SCLC.

Original languageEnglish (US)
Pages (from-to)6-8
Number of pages3
JournalCancer research
Issue number1
StatePublished - Jan 1994

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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