TY - JOUR
T1 - Experimental radioisotope irradiation of renal allografts in dogs
AU - Bonte, Frederick J.
AU - Peters, Paul C.
AU - Johnson, Donald
AU - Webb, Watts R.
AU - Stembridge, Bernie A.
N1 - Funding Information:
gratitude to Mrs. CAROLYN &BfON for her extraordinary diligence as the principal technican associated with this project. They also wish to thank Dr. PAUL NUMEROF, of the Radio-pharmaceutical Divisiono f E. R. Squibb & Sons, for his assistance in obtaining high specific activity 203Hg labeled chl ormerodrin and MHP. This work was supported in part by USPHS grants CRT 5136, FR 05426 and HE 05181.
PY - 1967/10
Y1 - 1967/10
N2 - Rejection of a canine renal allograft is accompanied by infiltration of the graft with lymphocytes and plasmacytes. External beam irradiation of the graft at intervals after transplantation has been employed to lower the population of these invading cells, and, in several laboratories, has been found to prolong host and graft survival. Described herein is a series of experiments in which chronic, low-dose irradiation of canine renal allograft was attempted by causing Mercury-203 to be deposited in graft renal tubular epithelium. Graft and host survivals were prolonged beyond control values for this laboratory in a few animals, but the general technique is not as yet adaptable to the human renal-transplantation problem.
AB - Rejection of a canine renal allograft is accompanied by infiltration of the graft with lymphocytes and plasmacytes. External beam irradiation of the graft at intervals after transplantation has been employed to lower the population of these invading cells, and, in several laboratories, has been found to prolong host and graft survival. Described herein is a series of experiments in which chronic, low-dose irradiation of canine renal allograft was attempted by causing Mercury-203 to be deposited in graft renal tubular epithelium. Graft and host survivals were prolonged beyond control values for this laboratory in a few animals, but the general technique is not as yet adaptable to the human renal-transplantation problem.
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U2 - 10.1016/0020-708X(67)90028-2
DO - 10.1016/0020-708X(67)90028-2
M3 - Article
C2 - 4861277
AN - SCOPUS:0014138189
SN - 0020-708X
VL - 18
SP - 689
EP - 695
JO - The International Journal Of Applied Radiation And Isotopes
JF - The International Journal Of Applied Radiation And Isotopes
IS - 10
ER -