Expeditious and practical synthesis of various substituted taurines from amino alcohols

Wei Zhang, Boyuan Wang, Ning Chen, Da Ming Du, Jiaxi Xu

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Various substituted taurines have been synthesized expeditiously and practically in satisfactory to good yields directly from amino alcohols using a two-step, one-pot procedure, in which the amino alcohols undergo sulfuric acid esterification and subsequent sodium sulfite substitution. Treatment of amino-substituted secondary alcohols using the same procedure gave 2-substituted or 1,2-disubstituted taurines, indicating the formation of aziridines as intermediates during the substitution step. This method is one of the most efficient routes for preparing structurally diverse 2-substituted and 1,2- and 2,2-disubstituted taurines.

Original languageEnglish (US)
Pages (from-to)197-200
Number of pages4
Issue number2
StatePublished - Jan 17 2008
Externally publishedYes


  • Amino acids
  • Amino alcohols, sulfates
  • Aminoalkanesulfonic acids
  • Taurines

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry


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