Abstract
Various substituted taurines have been synthesized expeditiously and practically in satisfactory to good yields directly from amino alcohols using a two-step, one-pot procedure, in which the amino alcohols undergo sulfuric acid esterification and subsequent sodium sulfite substitution. Treatment of amino-substituted secondary alcohols using the same procedure gave 2-substituted or 1,2-disubstituted taurines, indicating the formation of aziridines as intermediates during the substitution step. This method is one of the most efficient routes for preparing structurally diverse 2-substituted and 1,2- and 2,2-disubstituted taurines.
Original language | English (US) |
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Pages (from-to) | 197-200 |
Number of pages | 4 |
Journal | Synthesis |
Issue number | 2 |
DOIs | |
State | Published - Jan 17 2008 |
Externally published | Yes |
Keywords
- Amino acids
- Amino alcohols, sulfates
- Aminoalkanesulfonic acids
- Taurines
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry