Expansion of B cells is necessary for the induction of T-Cell tolerance elicited through the anterior chamber of the eye

Hossam M. Ashour; Jerry Y. Niederkorn

doi:10.1159/000106461

Expansion of B cells is necessary for the induction of T-Cell tolerance elicited through the anterior chamber of the eye

Hossam M. Ashour, Jerry Y. Niederkorn

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Antigens injected into the anterior chamber (AC) of the eye induce a form of peripheral immune tolerance termed anterior chamber-associated immune deviation (ACAID). ACAID is initiated by F4/80+ ocular antigen-presenting cells (APC) which capture ocular antigens and migrate to the spleen where they transfer antigenic peptides to B cells, which act as ancillary APC for the induction of T-regulatory cells (T_reg) that inhibit delayed-type hypersensitivity (DTH) responses. Here we show that ocular-like APC induce the expansion of tolerogenic splenic B cells. Furthermore, we show that inhibiting B-cell proliferation with either mitomycin-c or γ-irradiation abolishes the ability of B cells to induce T_reg. To our knowledge, this is the first study to report that B-cell proliferation is needed for B-cell-induced T-cell tolerance.

Original language	English (US)
Pages (from-to)	343-346
Number of pages	4
Journal	International Archives of Allergy and Immunology
Volume	144
Issue number	4
DOIs	https://doi.org/10.1159/000106461
State	Published - Nov 2007

Keywords

B cells
Immune privilege
Peripheral tolerance
T-regulatory cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1159/000106461

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title = "Expansion of B cells is necessary for the induction of T-Cell tolerance elicited through the anterior chamber of the eye",

abstract = "Antigens injected into the anterior chamber (AC) of the eye induce a form of peripheral immune tolerance termed anterior chamber-associated immune deviation (ACAID). ACAID is initiated by F4/80+ ocular antigen-presenting cells (APC) which capture ocular antigens and migrate to the spleen where they transfer antigenic peptides to B cells, which act as ancillary APC for the induction of T-regulatory cells (Treg) that inhibit delayed-type hypersensitivity (DTH) responses. Here we show that ocular-like APC induce the expansion of tolerogenic splenic B cells. Furthermore, we show that inhibiting B-cell proliferation with either mitomycin-c or γ-irradiation abolishes the ability of B cells to induce Treg. To our knowledge, this is the first study to report that B-cell proliferation is needed for B-cell-induced T-cell tolerance.",

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Expansion of B cells is necessary for the induction of T-Cell tolerance elicited through the anterior chamber of the eye

Abstract

Keywords

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