@article{22e7f79d9066485eba53fbaebd1a575e,
title = "Exercise-induced skeletal muscle adaptations alter the activity of adipose progenitor cells",
abstract = "Exercise decreases adiposity and improves metabolic health; however, the physiological and molecular underpinnings of these phenomena remain unknown. Here, we investigate the effect of endurance training on adipose progenitor lineage commitment. Using mice with genetically labeled adipose progenitors, we show that these cells react to exercise by decreasing their proliferation and differentiation potential. Analyses of mouse models that mimic the skeletal muscle adaptation to exercise indicate that muscle, in a non-autonomous manner, regulates adipose progenitor homeostasis, highlighting a role for muscle-derived secreted factors. These findings support a humoral link between skeletal muscle and adipose progenitors and indicate that manipulation of adipose stem cell function may help address obesity and diabetes.",
author = "Daniel Zeve and Millay, {Douglas P.} and Jin Seo and Graff, {Jonathan M.}",
note = "Funding Information: DZ: Predoctoral fellowship grant from the South Central Affiliate of the American Heart Association. DPM: National Institute of Health Ruth L. Kirschstein National Research Service Award (F32AR05948403). JS: Postdoctoral fellowship grant from the South Central Affiliate of the American Heart Association. JMG: National Institute of Health and the National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK066556, R01 DK064261 and R01 DK088220). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: Funding: DZ: Predoctoral fellowship grant from the South Central Affiliate of the American Heart Association. DPM: National Institute of Health Ruth L. Kirschstein National Research Service Award (F32AR05948403). JS: Postdoctoral fellowship grant Publisher Copyright: {\textcopyright} 2016 Zeve et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2016",
month = mar,
doi = "10.1371/journal.pone.0152129",
language = "English (US)",
volume = "11",
journal = "PloS one",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",
}