Examining the motor phenotype of patients with both essential tremor and parkinson’s disease

Rita M. Simões; Anne Constantino; Eliza Gibadullina; David Houghton; Elan D. Louis; Irene Litvan

doi:10.5334/TOHM.89

Examining the motor phenotype of patients with both essential tremor and parkinson’s disease

Rita M. Simões, Anne Constantino, Eliza Gibadullina, David Houghton, Elan D. Louis, Irene Litvan

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Background: The subset of patients with essential tremor (ET) that develops Parkinson’s disease (PD) has not been fully clinically characterized. Methods: Motor features were retrospectively reviewed in 18 ET patients who developed PD (ET→PD), 20 ET and 30 PD patients with similar ages and disease durations. Results: Fewer ET→PD than ET patients had widespread postural and/or action tremor (2/17 [11.8%] vs. 11/17 [64.7%]; p50.001) and marginally fewer had cerebellar signs (1/15 [6.7%] vs. 6/18 [33.3%], p50.06). ET→PD patients required fewer ET medications than did their counterparts with ET (p50.001). ETRPD patients and PD patients did not differ in UPDRS, Hoehn and Yahr, or Schwab and England scores (each p≥0.14). Discussion: ET patients who develop PD may have distinct pre-PD motor features compared to their counterparts with ET who do not develop co-existing PD. Prospective studies are needed to evaluate the predictive value of these clinical features for the emergence of PD.

Original language	English (US)
Journal	Tremor and Other Hyperkinetic Movements
Volume	2
DOIs	https://doi.org/10.5334/TOHM.89
State	Published - 2012
Externally published	Yes

Keywords

Essential tremor
Parkinson’s disease
Tremor severity

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.5334/TOHM.89

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@article{71fbb4762c9147f0bf2895961836d6a0,

title = "Examining the motor phenotype of patients with both essential tremor and parkinson{\textquoteright}s disease",

abstract = "Background: The subset of patients with essential tremor (ET) that develops Parkinson{\textquoteright}s disease (PD) has not been fully clinically characterized. Methods: Motor features were retrospectively reviewed in 18 ET patients who developed PD (ET→PD), 20 ET and 30 PD patients with similar ages and disease durations. Results: Fewer ET→PD than ET patients had widespread postural and/or action tremor (2/17 [11.8%] vs. 11/17 [64.7%]; p50.001) and marginally fewer had cerebellar signs (1/15 [6.7%] vs. 6/18 [33.3%], p50.06). ET→PD patients required fewer ET medications than did their counterparts with ET (p50.001). ETRPD patients and PD patients did not differ in UPDRS, Hoehn and Yahr, or Schwab and England scores (each p≥0.14). Discussion: ET patients who develop PD may have distinct pre-PD motor features compared to their counterparts with ET who do not develop co-existing PD. Prospective studies are needed to evaluate the predictive value of these clinical features for the emergence of PD.",

keywords = "Essential tremor, Parkinson{\textquoteright}s disease, Tremor severity",

author = "Sim{\~o}es, {Rita M.} and Anne Constantino and Eliza Gibadullina and David Houghton and Louis, {Elan D.} and Irene Litvan",

note = "Funding Information: * To whom correspondence should be addressed. E-mail: rita_moiron_simoes@hotmail.com Editor: Elan D. Louis, Columbia UniversityUnited States of America Received: June 19, 2011 Accepted: September 9, 2011 Published: May 21, 2012 Copyright: {\textquoteright} 2012 Sim{\~o}es et al. This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommercial–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original author(s) and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed. Funding: Dr. Louis was supported by NIH R01 NS039422 and NIH R01 NS042859. Competing Interests: The authors report no conflict of interest. Publisher Copyright: {\textcopyright} 2012 Sim{\~o}es et al.",

year = "2012",

doi = "10.5334/TOHM.89",

language = "English (US)",

volume = "2",

journal = "Tremor and Other Hyperkinetic Movements",

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T1 - Examining the motor phenotype of patients with both essential tremor and parkinson’s disease

AU - Simões, Rita M.

AU - Constantino, Anne

AU - Gibadullina, Eliza

AU - Houghton, David

AU - Louis, Elan D.

AU - Litvan, Irene

N1 - Funding Information: * To whom correspondence should be addressed. E-mail: rita_moiron_simoes@hotmail.com Editor: Elan D. Louis, Columbia UniversityUnited States of America Received: June 19, 2011 Accepted: September 9, 2011 Published: May 21, 2012 Copyright: ’ 2012 Simões et al. This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommercial–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original author(s) and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed. Funding: Dr. Louis was supported by NIH R01 NS039422 and NIH R01 NS042859. Competing Interests: The authors report no conflict of interest. Publisher Copyright: © 2012 Simões et al.

PY - 2012

Y1 - 2012

N2 - Background: The subset of patients with essential tremor (ET) that develops Parkinson’s disease (PD) has not been fully clinically characterized. Methods: Motor features were retrospectively reviewed in 18 ET patients who developed PD (ET→PD), 20 ET and 30 PD patients with similar ages and disease durations. Results: Fewer ET→PD than ET patients had widespread postural and/or action tremor (2/17 [11.8%] vs. 11/17 [64.7%]; p50.001) and marginally fewer had cerebellar signs (1/15 [6.7%] vs. 6/18 [33.3%], p50.06). ET→PD patients required fewer ET medications than did their counterparts with ET (p50.001). ETRPD patients and PD patients did not differ in UPDRS, Hoehn and Yahr, or Schwab and England scores (each p≥0.14). Discussion: ET patients who develop PD may have distinct pre-PD motor features compared to their counterparts with ET who do not develop co-existing PD. Prospective studies are needed to evaluate the predictive value of these clinical features for the emergence of PD.

AB - Background: The subset of patients with essential tremor (ET) that develops Parkinson’s disease (PD) has not been fully clinically characterized. Methods: Motor features were retrospectively reviewed in 18 ET patients who developed PD (ET→PD), 20 ET and 30 PD patients with similar ages and disease durations. Results: Fewer ET→PD than ET patients had widespread postural and/or action tremor (2/17 [11.8%] vs. 11/17 [64.7%]; p50.001) and marginally fewer had cerebellar signs (1/15 [6.7%] vs. 6/18 [33.3%], p50.06). ET→PD patients required fewer ET medications than did their counterparts with ET (p50.001). ETRPD patients and PD patients did not differ in UPDRS, Hoehn and Yahr, or Schwab and England scores (each p≥0.14). Discussion: ET patients who develop PD may have distinct pre-PD motor features compared to their counterparts with ET who do not develop co-existing PD. Prospective studies are needed to evaluate the predictive value of these clinical features for the emergence of PD.

KW - Essential tremor

KW - Parkinson’s disease

KW - Tremor severity

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ER -

Examining the motor phenotype of patients with both essential tremor and parkinson’s disease

Abstract

Keywords

ASJC Scopus subject areas

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