Ex vivo lung perfusion: how we do it

John Santosh Murala, William Michael Whited, Amit Banga, Robert Castillo, Matthias Peltz, Lynn Custer Huffman, Amy Elizabeth Hackmann, Michael Erik Jessen, Fernando Torres, Michael Alton Wait

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Lung transplantation is an established treatment for patients with end-stage lung disease. However, a shortage of donors, low lung utilization among potential donors, and waitlist mortality continue to be challenges. In the last decade, ex vivo lung perfusion (EVLP) has expanded the donor pool by allowing prolonged evaluation of marginal donor lungs and allowing reparative therapies for lungs, which are otherwise considered not transplantable. In this review, we describe in detail our experience with EVLP including our workflow, setup, operative technique, and protocols. Our multidisciplinary EVLP program functions with the collaboration of surgeons, pulmonologists, and EVLP nurses who run the pump. EVLP program has been a valuable addition to our program. Since Food and Drug Administration (FDA) approval in 2019, we experienced incremental increased lung transplant volume of 12% annually.

Original languageEnglish (US)
Pages (from-to)433-444
Number of pages12
JournalIndian Journal of Thoracic and Cardiovascular Surgery
StatePublished - Sep 2021


  • Donor selection
  • Ex vivo lung perfusion
  • Lung transplantation

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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