Evolving concepts in lung carcinogenesis

Brigitte N. Gomperts, Avrum Spira, Pierre P. Massion, Tonya C. Walser, Ignacio I. Wistuba, John D. Minna, Steven M. Dubinett

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Lung carcinogenesis is a complex, stepwise process that involves the acquisition of genetic mutations and epigenetic changes that alter cellular processes, such as proliferation, differentiation, invasion, and metastasis. Here, we review some of the latest concepts in the pathogenesis of lung cancer and highlight the roles of inflammation, the field of cancerization, and lung cancer stem cells in the initiation of the disease. Furthermore, we review how high throughput genomics, transcriptomics, epigenomics, and proteomics are advancing the study of lung carcinogenesis. Finally, we reflect on the potential of current in vitro and in vivo models of lung carcinogenesis to advance the field and on the areas of investigation where major breakthroughs will lead to the identification of novel chemoprevention strategies and therapies for lung cancer.

Original languageEnglish (US)
Pages (from-to)32-43
Number of pages12
JournalSeminars in Respiratory and Critical Care Medicine
Issue number1
StatePublished - 2011


  • Field of cancerization
  • epigenomics
  • genomics
  • inflammation
  • proteomics
  • stem cells

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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