Evolving Characteristics of Heart Transplantation Donors and Recipients: JACC Focus Seminar

Ersilia M. DeFilippis, Kiran K. Khush, Maryjane A. Farr, Amy Fiedler, Arman Kilic, Michael M. Givertz

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Although the burden of end-stage heart failure continues to increase, the number of available organs for heart transplantation (HT) remains inadequate. The HT community has been challenged to find ways to expand the number of donor hearts available. Recent advances include use of hearts from donors infected with hepatitis C virus as well as other previously underutilized donors, including those with left ventricular dysfunction, of older age, and with a history of cocaine use. Concurrently, emerging trends in HT surgery include donation after circulatory death, ex vivo normothermic heart perfusion, and controlled hypothermic preservation, which may enable procurement of organs from farther distances and prevent early allograft dysfunction. Contemporary HT recipients have also evolved in light of the 2018 revision to the U.S. heart allocation policy. This focus seminar discusses recent trends in donor and recipient phenotypes and management strategies for successful HT, as well as evolving areas and future directions.

Original languageEnglish (US)
Pages (from-to)1108-1123
Number of pages16
JournalJournal of the American College of Cardiology
Issue number11
StatePublished - Mar 22 2022


  • donation after circulatory death
  • donor selection
  • ex vivo normothermic perfusion
  • heart failure
  • heart transplantation
  • hepatitis C virus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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