@article{aa9038d44732404199395f93ad348707,
title = "Evidence for cortical dysfunction in spasmodic dysphonia: Regional cerebral blood flow and quantitative electrophysiology",
abstract = "Cortical function was evaluated in 26 subjects with spasmodic dysphonia. Quantitative topographic electrophysiologic mapping (QTE) was employed to provide quantitative analyses of EEG spectra and auditory and visual long-latency evoked potentials. Single-photon emission computed tomography (SPECT) of the cerebral transit of Xenon-133 was used to evaluate regional cerebral blood flow. Left hemispheric abnormalities in cortical function were found by both techniques in 10 subjects and by at least one technique in 18 subjects. Right hemispheric abnormalities were observed by both techniques in 8 subjects and by at least one technique in 18 subjects. Most patients with cortical dysfunction in one hemisphere had cortical dysfunction in the other, while only 4 subjects had unilateral lesions as found by one of the two techniques. Eight subjects were normal by all measurements. Underlying structural abnormalities were detected by magnetic resonance imaging in 5 24 subjects. However, functional abnormalities (SPECT or QTE) were not observed at sites of structural abnormalities. SPECT and QTE were significantly related in identification of left hemispheric dysfunction (p = .037) with a trend in the right hemisphere (p = .070), and a significant congruence of SPECT and QTE findings occurred in the left anterior cortical quadrant (p = .011). These findings indicate that dysfunction of cortical perfusion and/or cortical electrophysiology is associated with spasmodic dysphonia in the majority of subjects studied.",
author = "Devous, {M. D.} and Pool, {K. D.} and T. Finitzo and Freeman, {F. J.} and Schaefer, {S. D.} and Watson, {B. C.} and Kondraske, {G. V.} and Chapman, {S. B.}",
note = "Funding Information: Cortical function was evaluated in 26 subjects with spasmodic dysphonia. Quantitative topographic electrophysiologic mapping (QTE) was employed to provide quantitative analyses of EEG spectra and auditory and visual long-latency evoked potentials. Single-photon emission computed tomography (SPECT) of the cerebral transit of Xenon-133 was used to evaluate regional cerebral blood flow. Left hemispheric abnormalities in cortical function were found by both techniques in 10 subjects and by at least one technique in 18 subjects. Right hemispheric abnormalities were observed by both techniques in 8 subjects and by at least one technique in I8 subjects. Most patients with cortical dysfunction in one hemisphere had cortical dysfunction in the other, while only 4 subjects had unilateral lesions as found by one of the two techniques. Eight subjects were normal by all measurements. Underlying structural abnormalities were detected by magnetic resonance imaging in 5/24 subjects. However, functional abnormalities (SPECT or QTE) were not observed at sites of structural abnormalities. SPECT and QTE were signifcantly related in identification of left hemispheric dysfunction @ = ,037) with a trend in the right hemisphere (p = .070), and a significant congruence of SPECT and QTE findings occurred in the left anterior cortical quadrant (p = ,011). These findings indicate that dysfunction of cortical perfusion and/or cortical electrophysiology is associated with spasmodic dysphonia in the majority of subjects studied. o 1990 Academic PWF. IIK The authors acknowledge the expert technical assistance of A. Ajmani, W. Mosely, R. Pickett, B. Bite, and J. Rogers. This work was supported by NIH/NINCDS Grant No. 5-ROl NS18276. Please address reprint requests to Dr. Michael D. Devous, Sr., Nuclear Medicine Center, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9061.",
year = "1990",
month = aug,
doi = "10.1016/0093-934X(90)90018-C",
language = "English (US)",
volume = "39",
pages = "331--344",
journal = "Brain and language",
issn = "0093-934X",
publisher = "Academic Press Inc.",
number = "2",
}