Evaluation of newer treatment interventions for psychotic depression.

B. L. O'Neal, C. L. Smith, M. Trivedi

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Psychotic depression is characterized by greater severity, higher rate of recurrence, greater incapacitation, more frequent hospitalization, and longer episodes than nonpsychotic depression. The use of combined tricyclic antidepressants (TCAs) and neuroleptic therapy, as well as electroconvulsive therapy, has proven effectiveness in the treatment of psychotic depression. Although it is limited, evidence for efficacy of selective serontonin reuptake inhibitors both alone and in combination with antipsychotics in psychotic depression suggests that these strategies may provide a desirable alternative to the traditional TCA- neuroleptic therapy. These treatments, in addition to the continual introduction of new psychotropic agents suggest that the prospect of future research in this area is promising.

Original languageEnglish (US)
Pages (from-to)305-309
Number of pages5
JournalCurrent psychiatry reports
Issue number4
StatePublished - Aug 2000

ASJC Scopus subject areas

  • Psychiatry and Mental health


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