TY - JOUR
T1 - Evaluation of a radial diffusion plate method for determining serum immunoglobulin levels in normal and congenitally infected infants
AU - McCracken, George H.
AU - Hardy, Janet B.
AU - Chen, T. C.
AU - Sever, John L.
N1 - Funding Information:
From the Section on In\[ectious Diseases, The PerinataI Research Branch, and Office o\[ Biometry, National Institute o\[ Neurological Diseases and Blindness, the National Institutes o\[ Health, and The Johns Hopkins Medical Institutions. Supported in part by the National Institutes o\[ Health Grant No. NB 02371, and National Institutes o\[ Health Contracts Nos. PH 43 68 12 and PH 43 68 710.
PY - 1969/12
Y1 - 1969/12
N2 - Immunoglobulins were quantitated by a radial diffusion plate method. The values obtained on 2,600 cord sera, when submitted to statistical analysis, showed the technique to be both simple and satisfactory, provided a number of safeguards are taken to minimize the relatively large coefficient of variation in results obtained when sera with low IgM levels are tested. Elevation of cord IgM values was noted in 18 per cent of 88 infants with rubella tested, and principally in those with the more severe manifestations of the syndrome. Immunoglobulin values in 182 sera collected during the first 6 months of life were elevated in approximately half of the infants with rubella.
AB - Immunoglobulins were quantitated by a radial diffusion plate method. The values obtained on 2,600 cord sera, when submitted to statistical analysis, showed the technique to be both simple and satisfactory, provided a number of safeguards are taken to minimize the relatively large coefficient of variation in results obtained when sera with low IgM levels are tested. Elevation of cord IgM values was noted in 18 per cent of 88 infants with rubella tested, and principally in those with the more severe manifestations of the syndrome. Immunoglobulin values in 182 sera collected during the first 6 months of life were elevated in approximately half of the infants with rubella.
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U2 - 10.1016/s0022-3476(69)80376-8
DO - 10.1016/s0022-3476(69)80376-8
M3 - Article
C2 - 4187144
AN - SCOPUS:0014624323
SN - 0022-3476
VL - 75
SP - 1204
EP - 1210
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 6 PART 2
ER -