Evaluation of a Case Series of Patients with Palmoplantar Pustulosis in the United States

Megan H. Noe; Marilyn T. Wan; Arash Mostaghimi; Joel M. Gelfand; Ritesh Agnihothri; April W. Armstrong; Tina Bhutani; Alina Bridges; Nicholas Brownstone; Melissa Butt; Kristina P.Callis Duffin; Christian Carr; Andrew Creadore; Katherine L. Deniro; Sheena Desai; Arturo R. Dominguez; Emily K. Duffy; Janet A. Fairley; Alisa Femia; Johann E. Gudjonsson; Jessica A. Kaffenberger; Kimberly L. Katz; Joslyn S. Kirby; Stephanie T. Le; Edgar Martinez; Emanual Maverakis; Bridget Myers; Haley B. Naik; Caroline A. Nelson; Alex G. Ortega-Loayza; Molly E. Plovanich; Lauren K. Rangel; Vignesh Ravi; Vidhatha D. Reddy; Jamal Z. Saleh; Jeena K. Sandhu; Hadir Shakshouk; Bridget E. Shields; Zakariyah Sharif-Sidi; Jacob Smith; Amanda Steahr; Atrin Toussi; Karolyn A. Wanat; Bo Wang; Brian M. Wei; Annika Weinhammer; Scott D. Worswick; Alexander Yang

doi:10.1001/jamadermatol.2021.4635

Evaluation of a Case Series of Patients with Palmoplantar Pustulosis in the United States

Megan H. Noe, Marilyn T. Wan, Arash Mostaghimi, Joel M. Gelfand, Ritesh Agnihothri, April W. Armstrong, Tina Bhutani, Alina Bridges, Nicholas Brownstone, Melissa Butt, Kristina P.Callis Duffin, Christian Carr, Andrew Creadore, Katherine L. Deniro, Sheena Desai, Arturo R. Dominguez, Emily K. Duffy, Janet A. Fairley, Alisa Femia, Johann E. GudjonssonJessica A. Kaffenberger, Kimberly L. Katz, Joslyn S. Kirby, Stephanie T. Le, Edgar Martinez, Emanual Maverakis, Bridget Myers, Haley B. Naik, Caroline A. Nelson, Alex G. Ortega-Loayza, Molly E. Plovanich, Lauren K. Rangel, Vignesh Ravi, Vidhatha D. Reddy, Jamal Z. Saleh, Jeena K. Sandhu, Hadir Shakshouk, Bridget E. Shields, Zakariyah Sharif-Sidi, Jacob Smith, Amanda Steahr, Atrin Toussi, Karolyn A. Wanat, Bo Wang, Brian M. Wei, Annika Weinhammer, Scott D. Worswick, Alexander Yang

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Importance: Palmoplantar pustulosis (PPP) is a is a chronic, orphan disease with limited epidemiological data. Objective: To describe the clinical characteristics, treatments, longitudinal disease course, and health care utilization in adults with PPP across the US. Design, Setting, and Participants: This retrospective, longitudinal case series from 20 academic dermatology practices in the US included a consecutive sample of 197 adults who met the European Rare and Severe Psoriasis Expert Network consensus definition for PPP between January 1, 2007, and December 31, 2018. Data analysis was performed June 2020 to December 2020. Main Outcomes and Measures: The primary outcome was to describe the patient characteristics, associated medical comorbidities, treatment patterns, complications, and PPP-specific health care utilization. Results: Of 197 patients, 145 (73.6%) were female, and the mean (SD) age at presentation was 53.0 (12.6) years, with a mean (SD) follow-up time of 22.1 (28.0) months. On initial presentation, 95 (48.2%) patients reported skin pain, and 39 (19.8%) reported difficulty using hands and/or feet. Seventy patients (35.5%) were treated with systemic treatments, and use of more than 20 different systemic therapies was reported. In patients with at least 6 months of follow-up (n = 128), a median (IQR) of 3.7 (4-10) dermatology visits per year were reported; 24 (18.8%) patients had 5 or more visits during the study period. Conclusions and Relevance: In this case series, PPP was associated with persistent symptoms, continued health care utilization, and a lack of consensus regarding effective treatments, emphasizing the unmet medical need in this population. Additional research is necessary to understand treatment response in these patients.

Original language	English (US)
Pages (from-to)	68-72
Number of pages	5
Journal	JAMA Dermatology
Volume	158
Issue number	1
DOIs	https://doi.org/10.1001/jamadermatol.2021.4635
State	Published - Jan 2022
Externally published	Yes

ASJC Scopus subject areas

Dermatology

Access to Document

10.1001/jamadermatol.2021.4635

Cite this

Noe, M. H., Wan, M. T., Mostaghimi, A., Gelfand, J. M., Agnihothri, R., Armstrong, A. W., Bhutani, T., Bridges, A., Brownstone, N., Butt, M., Duffin, K. P. C., Carr, C., Creadore, A., Deniro, K. L., Desai, S., Dominguez, A. R., Duffy, E. K., Fairley, J. A., Femia, A., ... Yang, A. (2022). Evaluation of a Case Series of Patients with Palmoplantar Pustulosis in the United States. JAMA Dermatology, 158(1), 68-72. https://doi.org/10.1001/jamadermatol.2021.4635

Noe, MH, Wan, MT, Mostaghimi, A, Gelfand, JM, Agnihothri, R, Armstrong, AW, Bhutani, T, Bridges, A, Brownstone, N, Butt, M, Duffin, KPC, Carr, C, Creadore, A, Deniro, KL, Desai, S, Dominguez, AR, Duffy, EK, Fairley, JA, Femia, A, Gudjonsson, JE, Kaffenberger, JA, Katz, KL, Kirby, JS, Le, ST, Martinez, E, Maverakis, E, Myers, B, Naik, HB, Nelson, CA, Ortega-Loayza, AG, Plovanich, ME, Rangel, LK, Ravi, V, Reddy, VD, Saleh, JZ, Sandhu, JK, Shakshouk, H, Shields, BE, Sharif-Sidi, Z, Smith, J, Steahr, A, Toussi, A, Wanat, KA, Wang, B, Wei, BM, Weinhammer, A, Worswick, SD & Yang, A 2022, 'Evaluation of a Case Series of Patients with Palmoplantar Pustulosis in the United States', JAMA Dermatology, vol. 158, no. 1, pp. 68-72. https://doi.org/10.1001/jamadermatol.2021.4635

@article{227495eaa68047fe8c4549274ee83ca9,

title = "Evaluation of a Case Series of Patients with Palmoplantar Pustulosis in the United States",

abstract = "Importance: Palmoplantar pustulosis (PPP) is a is a chronic, orphan disease with limited epidemiological data. Objective: To describe the clinical characteristics, treatments, longitudinal disease course, and health care utilization in adults with PPP across the US. Design, Setting, and Participants: This retrospective, longitudinal case series from 20 academic dermatology practices in the US included a consecutive sample of 197 adults who met the European Rare and Severe Psoriasis Expert Network consensus definition for PPP between January 1, 2007, and December 31, 2018. Data analysis was performed June 2020 to December 2020. Main Outcomes and Measures: The primary outcome was to describe the patient characteristics, associated medical comorbidities, treatment patterns, complications, and PPP-specific health care utilization. Results: Of 197 patients, 145 (73.6%) were female, and the mean (SD) age at presentation was 53.0 (12.6) years, with a mean (SD) follow-up time of 22.1 (28.0) months. On initial presentation, 95 (48.2%) patients reported skin pain, and 39 (19.8%) reported difficulty using hands and/or feet. Seventy patients (35.5%) were treated with systemic treatments, and use of more than 20 different systemic therapies was reported. In patients with at least 6 months of follow-up (n = 128), a median (IQR) of 3.7 (4-10) dermatology visits per year were reported; 24 (18.8%) patients had 5 or more visits during the study period. Conclusions and Relevance: In this case series, PPP was associated with persistent symptoms, continued health care utilization, and a lack of consensus regarding effective treatments, emphasizing the unmet medical need in this population. Additional research is necessary to understand treatment response in these patients.",

author = "Noe, {Megan H.} and Wan, {Marilyn T.} and Arash Mostaghimi and Gelfand, {Joel M.} and Ritesh Agnihothri and Armstrong, {April W.} and Tina Bhutani and Alina Bridges and Nicholas Brownstone and Melissa Butt and Duffin, {Kristina P.Callis} and Christian Carr and Andrew Creadore and Deniro, {Katherine L.} and Sheena Desai and Dominguez, {Arturo R.} and Duffy, {Emily K.} and Fairley, {Janet A.} and Alisa Femia and Gudjonsson, {Johann E.} and Kaffenberger, {Jessica A.} and Katz, {Kimberly L.} and Kirby, {Joslyn S.} and Le, {Stephanie T.} and Edgar Martinez and Emanual Maverakis and Bridget Myers and Naik, {Haley B.} and Nelson, {Caroline A.} and Ortega-Loayza, {Alex G.} and Plovanich, {Molly E.} and Rangel, {Lauren K.} and Vignesh Ravi and Reddy, {Vidhatha D.} and Saleh, {Jamal Z.} and Sandhu, {Jeena K.} and Hadir Shakshouk and Shields, {Bridget E.} and Zakariyah Sharif-Sidi and Jacob Smith and Amanda Steahr and Atrin Toussi and Wanat, {Karolyn A.} and Bo Wang and Wei, {Brian M.} and Annika Weinhammer and Worswick, {Scott D.} and Alexander Yang",

year = "2022",

month = jan,

doi = "10.1001/jamadermatol.2021.4635",

language = "English (US)",

volume = "158",

pages = "68--72",

journal = "JAMA Dermatology",

issn = "2168-6068",

publisher = "American Medical Association",

number = "1",

}

TY - JOUR

T1 - Evaluation of a Case Series of Patients with Palmoplantar Pustulosis in the United States

AU - Noe, Megan H.

AU - Wan, Marilyn T.

AU - Mostaghimi, Arash

AU - Gelfand, Joel M.

AU - Agnihothri, Ritesh

AU - Armstrong, April W.

AU - Bhutani, Tina

AU - Bridges, Alina

AU - Brownstone, Nicholas

AU - Butt, Melissa

AU - Duffin, Kristina P.Callis

AU - Carr, Christian

AU - Creadore, Andrew

AU - Deniro, Katherine L.

AU - Desai, Sheena

AU - Dominguez, Arturo R.

AU - Duffy, Emily K.

AU - Fairley, Janet A.

AU - Femia, Alisa

AU - Gudjonsson, Johann E.

AU - Kaffenberger, Jessica A.

AU - Katz, Kimberly L.

AU - Kirby, Joslyn S.

AU - Le, Stephanie T.

AU - Martinez, Edgar

AU - Maverakis, Emanual

AU - Myers, Bridget

AU - Naik, Haley B.

AU - Nelson, Caroline A.

AU - Ortega-Loayza, Alex G.

AU - Plovanich, Molly E.

AU - Rangel, Lauren K.

AU - Ravi, Vignesh

AU - Reddy, Vidhatha D.

AU - Saleh, Jamal Z.

AU - Sandhu, Jeena K.

AU - Shakshouk, Hadir

AU - Shields, Bridget E.

AU - Sharif-Sidi, Zakariyah

AU - Smith, Jacob

AU - Steahr, Amanda

AU - Toussi, Atrin

AU - Wanat, Karolyn A.

AU - Wang, Bo

AU - Wei, Brian M.

AU - Weinhammer, Annika

AU - Worswick, Scott D.

AU - Yang, Alexander

PY - 2022/1

Y1 - 2022/1

N2 - Importance: Palmoplantar pustulosis (PPP) is a is a chronic, orphan disease with limited epidemiological data. Objective: To describe the clinical characteristics, treatments, longitudinal disease course, and health care utilization in adults with PPP across the US. Design, Setting, and Participants: This retrospective, longitudinal case series from 20 academic dermatology practices in the US included a consecutive sample of 197 adults who met the European Rare and Severe Psoriasis Expert Network consensus definition for PPP between January 1, 2007, and December 31, 2018. Data analysis was performed June 2020 to December 2020. Main Outcomes and Measures: The primary outcome was to describe the patient characteristics, associated medical comorbidities, treatment patterns, complications, and PPP-specific health care utilization. Results: Of 197 patients, 145 (73.6%) were female, and the mean (SD) age at presentation was 53.0 (12.6) years, with a mean (SD) follow-up time of 22.1 (28.0) months. On initial presentation, 95 (48.2%) patients reported skin pain, and 39 (19.8%) reported difficulty using hands and/or feet. Seventy patients (35.5%) were treated with systemic treatments, and use of more than 20 different systemic therapies was reported. In patients with at least 6 months of follow-up (n = 128), a median (IQR) of 3.7 (4-10) dermatology visits per year were reported; 24 (18.8%) patients had 5 or more visits during the study period. Conclusions and Relevance: In this case series, PPP was associated with persistent symptoms, continued health care utilization, and a lack of consensus regarding effective treatments, emphasizing the unmet medical need in this population. Additional research is necessary to understand treatment response in these patients.

AB - Importance: Palmoplantar pustulosis (PPP) is a is a chronic, orphan disease with limited epidemiological data. Objective: To describe the clinical characteristics, treatments, longitudinal disease course, and health care utilization in adults with PPP across the US. Design, Setting, and Participants: This retrospective, longitudinal case series from 20 academic dermatology practices in the US included a consecutive sample of 197 adults who met the European Rare and Severe Psoriasis Expert Network consensus definition for PPP between January 1, 2007, and December 31, 2018. Data analysis was performed June 2020 to December 2020. Main Outcomes and Measures: The primary outcome was to describe the patient characteristics, associated medical comorbidities, treatment patterns, complications, and PPP-specific health care utilization. Results: Of 197 patients, 145 (73.6%) were female, and the mean (SD) age at presentation was 53.0 (12.6) years, with a mean (SD) follow-up time of 22.1 (28.0) months. On initial presentation, 95 (48.2%) patients reported skin pain, and 39 (19.8%) reported difficulty using hands and/or feet. Seventy patients (35.5%) were treated with systemic treatments, and use of more than 20 different systemic therapies was reported. In patients with at least 6 months of follow-up (n = 128), a median (IQR) of 3.7 (4-10) dermatology visits per year were reported; 24 (18.8%) patients had 5 or more visits during the study period. Conclusions and Relevance: In this case series, PPP was associated with persistent symptoms, continued health care utilization, and a lack of consensus regarding effective treatments, emphasizing the unmet medical need in this population. Additional research is necessary to understand treatment response in these patients.

UR - http://www.scopus.com/inward/record.url?scp=85121229692&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85121229692&partnerID=8YFLogxK

U2 - 10.1001/jamadermatol.2021.4635

DO - 10.1001/jamadermatol.2021.4635

M3 - Article

C2 - 34878495

AN - SCOPUS:85121229692

SN - 2168-6068

VL - 158

SP - 68

EP - 72

JO - JAMA Dermatology

JF - JAMA Dermatology

IS - 1

ER -

Evaluation of a Case Series of Patients with Palmoplantar Pustulosis in the United States

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this