TY - JOUR
T1 - Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease
AU - ACCELERATE Investigators
AU - Lincoff, A. Michael
AU - Nicholls, Stephen J.
AU - Riesmeyer, Jeffrey S.
AU - Barter, Philip J.
AU - Brewer, H. Bryan
AU - Fox, Keith A.A.
AU - Gibson, C. Michael
AU - Granger, Christopher
AU - Menon, Venu
AU - Montalescot, Gilles
AU - Rader, Daniel
AU - Tall, Alan R.
AU - McErlean, Ellen
AU - Wolski, Kathy
AU - Ruotolo, Giacomo
AU - Vangerow, Burkhard
AU - Weerakkody, Govinda
AU - Goodman, Shaun G.
AU - Conde, Diego
AU - McGuire, Darren K
AU - Nicolau, Jose C.
AU - Leiva-Pons, Jose L.
AU - Pesant, Yves
AU - Li, Weimin
AU - Kandath, David
AU - Kouz, Simon
AU - Tahirkheli, Naeem
AU - Mason, Denise
AU - Nissen, Steven E.
N1 - Publisher Copyright:
Copyright © 2017 Massachusetts Medical Society.
PY - 2017/5/18
Y1 - 2017/5/18
N2 - BACKGROUND: The cholesteryl ester transfer protein inhibitor evacetrapib substantially raises the high-density lipoprotein (HDL) cholesterol level, reduces the low-density lipoprotein (LDL) cholesterol level, and enhances cellular cholesterol efflux capacity. We sought to determine the effect of evacetrapib on major adverse cardiovascular outcomes in patients with high-risk vascular disease. METHODS: In a multicenter, randomized, double-blind, placebo-controlled phase 3 trial, we enrolled 12,092 patients who had at least one of the following conditions: an acute coronary syndrome within the previous 30 to 365 days, cerebrovascular atherosclerotic disease, peripheral vascular arterial disease, or diabetes mellitus with coronary artery disease. Patients were randomly assigned to receive either evacetrapib at a dose of 130 mg or matching placebo, administered daily, in addition to standard medical therapy. The primary efficacy end point was the first occurrence of any component of the composite of death from cardiovascular causes, myocardial infarction, stroke, coronary revascularization, or hospitalization for unstable angina. RESULTS: At 3 months, a 31.1% decrease in the mean LDL cholesterol level was observed with evacetrapib versus a 6.0% increase with placebo, and a 133.2% increase in the mean HDL cholesterol level was seen with evacetrapib versus a 1.6% increase with placebo. After 1363 of the planned 1670 primary end-point events had occurred, the data and safety monitoring board recommended that the trial be terminated early because of a lack of efficacy. After a median of 26 months of evacetrapib or placebo, a primary end-point event occurred in 12.9% of the patients in the evacetrapib group and in 12.8% of those in the placebo group (hazard ratio, 1.01; 95% confidence interval, 0.91 to 1.11; P = 0.91). CONCLUSIONS: Although the cholesteryl ester transfer protein inhibitor evacetrapib had favorable effects on established lipid biomarkers, treatment with evacetrapib did not result in a lower rate of cardiovascular events than placebo among patients with high-risk vascular disease.
AB - BACKGROUND: The cholesteryl ester transfer protein inhibitor evacetrapib substantially raises the high-density lipoprotein (HDL) cholesterol level, reduces the low-density lipoprotein (LDL) cholesterol level, and enhances cellular cholesterol efflux capacity. We sought to determine the effect of evacetrapib on major adverse cardiovascular outcomes in patients with high-risk vascular disease. METHODS: In a multicenter, randomized, double-blind, placebo-controlled phase 3 trial, we enrolled 12,092 patients who had at least one of the following conditions: an acute coronary syndrome within the previous 30 to 365 days, cerebrovascular atherosclerotic disease, peripheral vascular arterial disease, or diabetes mellitus with coronary artery disease. Patients were randomly assigned to receive either evacetrapib at a dose of 130 mg or matching placebo, administered daily, in addition to standard medical therapy. The primary efficacy end point was the first occurrence of any component of the composite of death from cardiovascular causes, myocardial infarction, stroke, coronary revascularization, or hospitalization for unstable angina. RESULTS: At 3 months, a 31.1% decrease in the mean LDL cholesterol level was observed with evacetrapib versus a 6.0% increase with placebo, and a 133.2% increase in the mean HDL cholesterol level was seen with evacetrapib versus a 1.6% increase with placebo. After 1363 of the planned 1670 primary end-point events had occurred, the data and safety monitoring board recommended that the trial be terminated early because of a lack of efficacy. After a median of 26 months of evacetrapib or placebo, a primary end-point event occurred in 12.9% of the patients in the evacetrapib group and in 12.8% of those in the placebo group (hazard ratio, 1.01; 95% confidence interval, 0.91 to 1.11; P = 0.91). CONCLUSIONS: Although the cholesteryl ester transfer protein inhibitor evacetrapib had favorable effects on established lipid biomarkers, treatment with evacetrapib did not result in a lower rate of cardiovascular events than placebo among patients with high-risk vascular disease.
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U2 - 10.1056/NEJMoa1609581
DO - 10.1056/NEJMoa1609581
M3 - Article
C2 - 28514624
AN - SCOPUS:85019790381
SN - 0028-4793
VL - 376
SP - 1933
EP - 1942
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 20
ER -