Abstract
PARACEST redox sensors containing the NAD +/NADH mimic N-methylquinolinium moiety as a redox-active functional group have been designed and synthesized. The Eu 3+ complex with two quinolinium moieties was nearly completely CEST-silent in the oxidized form but was "turned on" upon reduction with β-NADH. The CEST effect of the Eu 3+ complex containing only one quinolinium group was much less redox-responsive but showed an unexpected sensitivity to pH in the physiologically relevant pH range.
Original language | English (US) |
---|---|
Pages (from-to) | 5798-5800 |
Number of pages | 3 |
Journal | Journal of the American Chemical Society |
Volume | 134 |
Issue number | 13 |
DOIs | |
State | Published - Apr 4 2012 |
ASJC Scopus subject areas
- Catalysis
- General Chemistry
- Biochemistry
- Colloid and Surface Chemistry