Eukaryotic transcription initiation machinery visualized at molecular level

Yan Han; Yuan He

doi:10.1080/21541264.2016.1237150

Eukaryotic transcription initiation machinery visualized at molecular level

Yan Han, Yuan He

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

The structures of RNA Polymerase (Pol) II pre-initiation complexes (PIC) have recently been determined at near-atomic resolution, elucidating unprecedented mechanistic details of promoter opening during transcription initiation. The key structural features of promoter opening are summarized here. Structural knowledge of Pol I and III PIC is also briefly discussed.

Original language	English (US)
Pages (from-to)	203-208
Number of pages	6
Journal	Transcription
Volume	7
Issue number	5
DOIs	https://doi.org/10.1080/21541264.2016.1237150
State	Published - Oct 19 2016
Externally published	Yes

Keywords

RNA polymerase
general transcription factor
pre-initiation complex
promoter opening
transcription initiation

ASJC Scopus subject areas

Biotechnology
Biochemistry
Genetics

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10.1080/21541264.2016.1237150

Cite this

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title = "Eukaryotic transcription initiation machinery visualized at molecular level",

abstract = "The structures of RNA Polymerase (Pol) II pre-initiation complexes (PIC) have recently been determined at near-atomic resolution, elucidating unprecedented mechanistic details of promoter opening during transcription initiation. The key structural features of promoter opening are summarized here. Structural knowledge of Pol I and III PIC is also briefly discussed.",

keywords = "RNA polymerase, general transcription factor, pre-initiation complex, promoter opening, transcription initiation",

author = "Yan Han and Yuan He",

note = "Publisher Copyright: {\textcopyright} 2016 Taylor & Francis.",

year = "2016",

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doi = "10.1080/21541264.2016.1237150",

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T1 - Eukaryotic transcription initiation machinery visualized at molecular level

AU - Han, Yan

AU - He, Yuan

PY - 2016/10/19

Y1 - 2016/10/19

N2 - The structures of RNA Polymerase (Pol) II pre-initiation complexes (PIC) have recently been determined at near-atomic resolution, elucidating unprecedented mechanistic details of promoter opening during transcription initiation. The key structural features of promoter opening are summarized here. Structural knowledge of Pol I and III PIC is also briefly discussed.

AB - The structures of RNA Polymerase (Pol) II pre-initiation complexes (PIC) have recently been determined at near-atomic resolution, elucidating unprecedented mechanistic details of promoter opening during transcription initiation. The key structural features of promoter opening are summarized here. Structural knowledge of Pol I and III PIC is also briefly discussed.

KW - RNA polymerase

KW - general transcription factor

KW - pre-initiation complex

KW - promoter opening

KW - transcription initiation

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U2 - 10.1080/21541264.2016.1237150

DO - 10.1080/21541264.2016.1237150

M3 - Review article

C2 - 27658022

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SN - 2154-1264

VL - 7

SP - 203

EP - 208

JO - Transcription

JF - Transcription

IS - 5

ER -

Eukaryotic transcription initiation machinery visualized at molecular level

Abstract

Keywords

ASJC Scopus subject areas

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