TY - JOUR
T1 - Etiology of Syncope in Patients Hospitalized with Syncope and Predictors of Mortality and Readmission for Syncope at 17-Month Follow-Up
T2 - A Prospective Study
AU - Sule, Sachin
AU - Palaniswamy, Chandrasekar
AU - Aronow, Wilbert S.
AU - Adapa, Sreedhar
AU - Khera, Sahil
AU - Peterson, Stephen J.
AU - Ahn, Chul
AU - Balasubramaniyam, Nivas
AU - Nabors, Christopher
PY - 2016/1/1
Y1 - 2016/1/1
N2 - We investigated the etiologies of syncope and risk factors for mortality and rehospitalization for syncope at 17-month follow-up in a prospective study of 242 consecutive patients, mean age 69 years, hospitalized for syncope. The etiologies of syncope included the following: vasovagal syncope in 49 patients (20%), volume depletion in 39 patients (16%), orthostatic hypotension in 13 patients (5%), primary cardiac arrhythmias in 25 patients (10.3%), structural cardiac disease in 6 patients (2%), and drug overdose in 5 patients (2%). The etiology of syncope could not be determined in 84 patients (35%). Of the 242 patients, 6 (2%) were rehospitalized for syncope and 12 (5%) died. Stepwise logistic regression analysis showed that the significant independent prognostic factors for rehospitalization for syncope were drug overdose [odds ratio (OR): 11.506; 95% confidence interval (CI): 1.083 - 22.261]. Stepwise logistic regression analysis showed that significant independent prognostic factors for time to mortality were undetermined etiology of syncope (OR: 4.665; 95% CI: 1.002, 21.727), San Francisco Syncope Score (OR: 3.537; 95% CI: 1.472-8.496), hypertension (OR: 0.099; 95% CI: 0.019-0.504), and glomerular filtration rate (OR: 0.964; 95% CI: 0.937-0.993).
AB - We investigated the etiologies of syncope and risk factors for mortality and rehospitalization for syncope at 17-month follow-up in a prospective study of 242 consecutive patients, mean age 69 years, hospitalized for syncope. The etiologies of syncope included the following: vasovagal syncope in 49 patients (20%), volume depletion in 39 patients (16%), orthostatic hypotension in 13 patients (5%), primary cardiac arrhythmias in 25 patients (10.3%), structural cardiac disease in 6 patients (2%), and drug overdose in 5 patients (2%). The etiology of syncope could not be determined in 84 patients (35%). Of the 242 patients, 6 (2%) were rehospitalized for syncope and 12 (5%) died. Stepwise logistic regression analysis showed that the significant independent prognostic factors for rehospitalization for syncope were drug overdose [odds ratio (OR): 11.506; 95% confidence interval (CI): 1.083 - 22.261]. Stepwise logistic regression analysis showed that significant independent prognostic factors for time to mortality were undetermined etiology of syncope (OR: 4.665; 95% CI: 1.002, 21.727), San Francisco Syncope Score (OR: 3.537; 95% CI: 1.472-8.496), hypertension (OR: 0.099; 95% CI: 0.019-0.504), and glomerular filtration rate (OR: 0.964; 95% CI: 0.937-0.993).
KW - mortality
KW - rehospitalization
KW - syncope
UR - http://www.scopus.com/inward/record.url?scp=84955462192&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955462192&partnerID=8YFLogxK
U2 - 10.1097/MJT.0b013e3182459957
DO - 10.1097/MJT.0b013e3182459957
M3 - Article
C2 - 22878409
AN - SCOPUS:84955462192
SN - 1075-2765
VL - 23
SP - e2-e6
JO - American Journal of Therapeutics
JF - American Journal of Therapeutics
IS - 1
ER -