TY - JOUR
T1 - Establishing preference for lidocaine solution to water
T2 - Comparison between a fading and an abrupt-removal procedure for withdrawing a compound vehicle
AU - Falk, J. L.
AU - Yosef, E.
AU - Kuo, C.
AU - Farooque, P.
AU - Lau, C. E.
PY - 1999
Y1 - 1999
N2 - Rats were exposed to daily, 3-h, fixed-time 1-min food pellet delivery sessions, which is a procedure that produces overdrinking (schedule-induced polydipsia). In previous polydipsia studies, rats came to prefer solutions of drug or non-drug agents to concurrently presented water if the agents had first been offered in a glucose-saccharin vehicle that was slowly eliminated (faded), leaving a choice between a substance in water vehicle vs water. In the first experiment, a more rapid vehicle-fading procedure was used to produce a preference for 0.19 mg/ml lidocaine to water. In the second experiment, the vehicle was abruptly changed to water, which also resulted in a strong preference for lidocaine solution, although the lidocaine solution volumes ingested for the final sessions were significantly less than in the first experiment. The results are consistent with a conditioned flavor/nutrient preference interpretation for the institution of the lidocaine preference in both experiments. Although flavor/nutrient conditioning can be a sufficient condition for generating a substance preference, a previous experiment showed that it was not a necessary condition.
AB - Rats were exposed to daily, 3-h, fixed-time 1-min food pellet delivery sessions, which is a procedure that produces overdrinking (schedule-induced polydipsia). In previous polydipsia studies, rats came to prefer solutions of drug or non-drug agents to concurrently presented water if the agents had first been offered in a glucose-saccharin vehicle that was slowly eliminated (faded), leaving a choice between a substance in water vehicle vs water. In the first experiment, a more rapid vehicle-fading procedure was used to produce a preference for 0.19 mg/ml lidocaine to water. In the second experiment, the vehicle was abruptly changed to water, which also resulted in a strong preference for lidocaine solution, although the lidocaine solution volumes ingested for the final sessions were significantly less than in the first experiment. The results are consistent with a conditioned flavor/nutrient preference interpretation for the institution of the lidocaine preference in both experiments. Although flavor/nutrient conditioning can be a sufficient condition for generating a substance preference, a previous experiment showed that it was not a necessary condition.
KW - Associative history
KW - Conditioned flavor preference
KW - Drug preference
KW - Lidocaine
KW - Oral drug
KW - Oral self-administration
KW - Rat
KW - Schedule-induced behavior
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U2 - 10.1097/00008877-199912000-00012
DO - 10.1097/00008877-199912000-00012
M3 - Article
C2 - 10780296
AN - SCOPUS:0033396671
SN - 0955-8810
VL - 10
SP - 803
EP - 808
JO - Behavioural Pharmacology
JF - Behavioural Pharmacology
IS - 8
ER -