TY - JOUR
T1 - Essential tremor-Parkinson's disease
T2 - A double whammy
AU - Louis, Elan D.
AU - Wise, Adina
AU - Alcalay, Roy N.
AU - Rao, Ashwini K.
AU - Factor-Litvak, Pam
N1 - Funding Information:
Dr. Louis has received research support from the National Institutes of Health: NINDS R01 NS042859 (principal investigator), NINDS R01 NS39422 (principal investigator), NINDS R01 NS086736 (principal investigator), NINDS R01 NS073872 (principal investigator), NINDS R01 NS085136 (principal investigator) and NINDS R01 NS088257 (principal investigator).
Publisher Copyright:
© 2016 Elsevier B.V. All rights reserved.
PY - 2016/7/15
Y1 - 2016/7/15
N2 - Background Surprisingly little has been written about the combined clinical entity, essential tremor-Parkinson's disease (ET-PD), which is the result of a double disease hit. We carefully quantified tremor burden using a wide range of measures (tremor severity, tremor-related disability, tremor-related quality of life) and furthermore, studied additional motor and non-motor features in ET-PD. Methods In this prospective, clinical-epidemiological study, we performed a standardized, structured clinical evaluation of 27 ET-PD patients, comparing them to age-matched samples of 35 PD and 109 ET patients. Results The number of hours/day shaking was lowest in PD (median = 3.0), intermediate in ET (median = 10.0) and highest in ET-PD (median = 14.0) (p < 0.001). All measures of mobility and balance (Berg Balance test, Activities-specific Balance Confidence Scale, Timed Up and Go test) worsened across groups in a stepwise manner from ET to PD to ET-PD (p < 0.05). Mini-mental state test scores worsened (p = 0.002) and daytime sleepiness increased (p = 0.002) across groups from ET to PD to ET-PD. Conclusions The ET-PD patient seems to be more than just a PD patient with a little more kinetic tremor. Aside from a significantly greater tremor burden, ET-PD patients exhibited more cognitive and sleep problems and more mobility and balance problems than patients with isolated PD.
AB - Background Surprisingly little has been written about the combined clinical entity, essential tremor-Parkinson's disease (ET-PD), which is the result of a double disease hit. We carefully quantified tremor burden using a wide range of measures (tremor severity, tremor-related disability, tremor-related quality of life) and furthermore, studied additional motor and non-motor features in ET-PD. Methods In this prospective, clinical-epidemiological study, we performed a standardized, structured clinical evaluation of 27 ET-PD patients, comparing them to age-matched samples of 35 PD and 109 ET patients. Results The number of hours/day shaking was lowest in PD (median = 3.0), intermediate in ET (median = 10.0) and highest in ET-PD (median = 14.0) (p < 0.001). All measures of mobility and balance (Berg Balance test, Activities-specific Balance Confidence Scale, Timed Up and Go test) worsened across groups in a stepwise manner from ET to PD to ET-PD (p < 0.05). Mini-mental state test scores worsened (p = 0.002) and daytime sleepiness increased (p = 0.002) across groups from ET to PD to ET-PD. Conclusions The ET-PD patient seems to be more than just a PD patient with a little more kinetic tremor. Aside from a significantly greater tremor burden, ET-PD patients exhibited more cognitive and sleep problems and more mobility and balance problems than patients with isolated PD.
KW - Clinical
KW - Essential tremor
KW - Parkinson's disease
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U2 - 10.1016/j.jns.2016.04.040
DO - 10.1016/j.jns.2016.04.040
M3 - Article
C2 - 27288775
AN - SCOPUS:84966963766
SN - 0022-510X
VL - 366
SP - 47
EP - 51
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
ER -