TY - JOUR
T1 - Essential tremor-Parkinson's disease
T2 - A double whammy
AU - Louis, Elan D.
AU - Wise, Adina
AU - Alcalay, Roy N.
AU - Rao, Ashwini K.
AU - Factor-Litvak, Pam
N1 - Publisher Copyright:
© 2016 Elsevier B.V. All rights reserved.
PY - 2016/7/15
Y1 - 2016/7/15
N2 - Background Surprisingly little has been written about the combined clinical entity, essential tremor-Parkinson's disease (ET-PD), which is the result of a double disease hit. We carefully quantified tremor burden using a wide range of measures (tremor severity, tremor-related disability, tremor-related quality of life) and furthermore, studied additional motor and non-motor features in ET-PD. Methods In this prospective, clinical-epidemiological study, we performed a standardized, structured clinical evaluation of 27 ET-PD patients, comparing them to age-matched samples of 35 PD and 109 ET patients. Results The number of hours/day shaking was lowest in PD (median = 3.0), intermediate in ET (median = 10.0) and highest in ET-PD (median = 14.0) (p < 0.001). All measures of mobility and balance (Berg Balance test, Activities-specific Balance Confidence Scale, Timed Up and Go test) worsened across groups in a stepwise manner from ET to PD to ET-PD (p < 0.05). Mini-mental state test scores worsened (p = 0.002) and daytime sleepiness increased (p = 0.002) across groups from ET to PD to ET-PD. Conclusions The ET-PD patient seems to be more than just a PD patient with a little more kinetic tremor. Aside from a significantly greater tremor burden, ET-PD patients exhibited more cognitive and sleep problems and more mobility and balance problems than patients with isolated PD.
AB - Background Surprisingly little has been written about the combined clinical entity, essential tremor-Parkinson's disease (ET-PD), which is the result of a double disease hit. We carefully quantified tremor burden using a wide range of measures (tremor severity, tremor-related disability, tremor-related quality of life) and furthermore, studied additional motor and non-motor features in ET-PD. Methods In this prospective, clinical-epidemiological study, we performed a standardized, structured clinical evaluation of 27 ET-PD patients, comparing them to age-matched samples of 35 PD and 109 ET patients. Results The number of hours/day shaking was lowest in PD (median = 3.0), intermediate in ET (median = 10.0) and highest in ET-PD (median = 14.0) (p < 0.001). All measures of mobility and balance (Berg Balance test, Activities-specific Balance Confidence Scale, Timed Up and Go test) worsened across groups in a stepwise manner from ET to PD to ET-PD (p < 0.05). Mini-mental state test scores worsened (p = 0.002) and daytime sleepiness increased (p = 0.002) across groups from ET to PD to ET-PD. Conclusions The ET-PD patient seems to be more than just a PD patient with a little more kinetic tremor. Aside from a significantly greater tremor burden, ET-PD patients exhibited more cognitive and sleep problems and more mobility and balance problems than patients with isolated PD.
KW - Clinical
KW - Essential tremor
KW - Parkinson's disease
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U2 - 10.1016/j.jns.2016.04.040
DO - 10.1016/j.jns.2016.04.040
M3 - Article
C2 - 27288775
AN - SCOPUS:84966963766
SN - 0022-510X
VL - 366
SP - 47
EP - 51
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
ER -