TY - JOUR
T1 - ER-to-mitochondria miscommunication and metabolic diseases
AU - López-Crisosto, Camila
AU - Bravo-Sagua, Roberto
AU - Rodriguez-Peña, Marcelo
AU - Mera, Claudia
AU - Castro, Pablo F.
AU - Quest, Andrew F G
AU - Rothermel, Beverly A.
AU - Cifuentes, Mariana
AU - Lavandero, Sergio
N1 - Funding Information:
This work was funded by the Comision Nacional de Ciencia y Tecnologia (CONICYT) , Chile: FONDECYT 1120212 to SL; FONDECYT 1110157 to MC; FONDAP 15130011 to SL, PFC, AFGQ; CONICYT Postdoctoral Fellowship to MRP and PhD fellowships to RB and CLC, and the National Institutes of Health , USA: R01 HL097768 to BAR.
Publisher Copyright:
© 2015 Elsevier B.V..
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Eukaryotic cells contain a variety of subcellular organelles, each of which performs unique tasks. Thus follows that in order to coordinate these different intracellular functions, a highly dynamic system of communication must exist between the various compartments. Direct endoplasmic reticulum (ER)-mitochondria communication is facilitated by the physical interaction of their membranes in dedicated structural domains known as mitochondria-associated membranes (MAMs), which facilitate calcium (Ca2+) and lipid transfer between organelles and also act as platforms for signaling. Numerous studies have demonstrated the importance of MAM in ensuring correct function of both organelles, and recently MAMs have been implicated in the genesis of various human diseases. Here, we review the salient structural features of interorganellar communication via MAM and discuss the most common experimental techniques employed to assess functionality of these domains. Finally, we will highlight the contribution of MAM to a variety of cellular functions and consider the potential role of MAM in the genesis of metabolic diseases. In doing so, the importance for cell functions of maintaining appropriate communication between ER and mitochondria will be emphasized.
AB - Eukaryotic cells contain a variety of subcellular organelles, each of which performs unique tasks. Thus follows that in order to coordinate these different intracellular functions, a highly dynamic system of communication must exist between the various compartments. Direct endoplasmic reticulum (ER)-mitochondria communication is facilitated by the physical interaction of their membranes in dedicated structural domains known as mitochondria-associated membranes (MAMs), which facilitate calcium (Ca2+) and lipid transfer between organelles and also act as platforms for signaling. Numerous studies have demonstrated the importance of MAM in ensuring correct function of both organelles, and recently MAMs have been implicated in the genesis of various human diseases. Here, we review the salient structural features of interorganellar communication via MAM and discuss the most common experimental techniques employed to assess functionality of these domains. Finally, we will highlight the contribution of MAM to a variety of cellular functions and consider the potential role of MAM in the genesis of metabolic diseases. In doing so, the importance for cell functions of maintaining appropriate communication between ER and mitochondria will be emphasized.
KW - Endoplasmic reticulum
KW - Interorganelle communication
KW - Metabolic diseases
KW - Mitochondria
KW - Mitochondria-associated membranes
KW - Mitochondrial metabolism
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U2 - 10.1016/j.bbadis.2015.07.011
DO - 10.1016/j.bbadis.2015.07.011
M3 - Review article
C2 - 26171812
AN - SCOPUS:84938217139
SN - 0925-4439
VL - 1852
SP - 2096
EP - 2105
JO - Biochimica et Biophysica Acta - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
IS - 10
ER -