TY - JOUR
T1 - ER chaperones in mammalian development and human diseases
AU - Ni, Min
AU - Lee, Amy S.
N1 - Funding Information:
This work was supported in part by the NIH Grants CA27607 and CA111700 (A.S.L). We thank Changhui Mao, Risheng Ye and members of the Lee laboratory for helpful discussions.
PY - 2007/7/31
Y1 - 2007/7/31
N2 - The field of endoplasmic reticulum (ER) stress in mammalian cells has expanded rapidly during the past decade, contributing to understanding of the molecular pathways that allow cells to adapt to perturbations in ER homeostasis. One major mechanism is mediated by molecular ER chaperones which are critical not only for quality control of proteins processed in the ER, but also for regulation of ER signaling in response to ER stress. Here, we summarized the properties and functions of GRP78/BiP, GRP94/gp96, GRP170/ORP150, GRP58/ERp57, PDI, ERp72, calnexin, calreticulin, EDEM, Herp and co-chaperones SIL1 and P58IPK and their role in development and diseases. Many of the new insights are derived from recently constructed mouse models where the genes encoding the chaperones are genetically altered, providing invaluable tools for examining the physiological involvement of the ER chaperones in vivo.
AB - The field of endoplasmic reticulum (ER) stress in mammalian cells has expanded rapidly during the past decade, contributing to understanding of the molecular pathways that allow cells to adapt to perturbations in ER homeostasis. One major mechanism is mediated by molecular ER chaperones which are critical not only for quality control of proteins processed in the ER, but also for regulation of ER signaling in response to ER stress. Here, we summarized the properties and functions of GRP78/BiP, GRP94/gp96, GRP170/ORP150, GRP58/ERp57, PDI, ERp72, calnexin, calreticulin, EDEM, Herp and co-chaperones SIL1 and P58IPK and their role in development and diseases. Many of the new insights are derived from recently constructed mouse models where the genes encoding the chaperones are genetically altered, providing invaluable tools for examining the physiological involvement of the ER chaperones in vivo.
KW - Chaperones
KW - Diseases
KW - Endoplasmic reticulum
KW - Mammalian development
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U2 - 10.1016/j.febslet.2007.04.045
DO - 10.1016/j.febslet.2007.04.045
M3 - Short survey
C2 - 17481612
AN - SCOPUS:34447558236
SN - 0014-5793
VL - 581
SP - 3641
EP - 3651
JO - FEBS Letters
JF - FEBS Letters
IS - 19
ER -