@article{4b6597c14f4f441c9f2d02b096a18422,
title = "Epithelial-Derived Reactive Oxygen Species Enable AppBCX-Mediated Aerobic Respiration of Escherichia coli during Intestinal Inflammation",
abstract = "During inflammation, the intestinal epithelium produces antimicrobial products to impede bacterial growth. Chanin et al., report that one of these antimicrobial products, reactive oxygen species, also promotes the outgrowth of E. coli. Detoxification of inflammatory reactive oxygen species through AppBCX allows E. coli to respire in an otherwise anaerobic environment.",
keywords = "cytochrome oxidase, gut inflammation, gut microbiota dysbiosis, intestinal epithelium, microbial respiration, reactive oxygen species",
author = "Chanin, {Rachael B.} and Winter, {Maria G.} and Luisella Spiga and Hughes, {Elizabeth R.} and Wenhan Zhu and Taylor, {Savannah J.} and Alexandre Arenales and Gillis, {Caroline C.} and Lisa B{\"u}ttner and Jimenez, {Angel G.} and Smoot, {Madeline P.} and Santos, {Renato L.} and Winter, {Sebastian E.}",
note = "Funding Information: We thank Drs. Jessica Moreland, Vanessa Sperandio, and Julie Pfeiffer (UT Southwestern Medical Center) for helpful discussions. Work in S. E.W.{\textquoteright}s lab was funded by the Welch Foundation ( I-1969-20180324 ), NIH ( AI118807 , AI128151 ), the Burroughs Wellcome Fund ( 1017880 ), and a Research Scholar grant ( RSG-17-048-01-MPC ) from the American Cancer Society . R.C. was in part supported by T32 training grant AI007520 and W.Z. was supported by a Research Fellows Award from the Crohn{\textquoteright}s and Colitis Foundation ( 454921 ). Any opinions, findings, conclusions, or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the funding agencies. The funders had no role in study design, data collection, interpretation, or decision to submit the work for publication. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = dec,
day = "9",
doi = "10.1016/j.chom.2020.09.005",
language = "English (US)",
volume = "28",
pages = "780--788.e5",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "6",
}