Abstract
During inflammation, the intestinal epithelium produces antimicrobial products to impede bacterial growth. Chanin et al., report that one of these antimicrobial products, reactive oxygen species, also promotes the outgrowth of E. coli. Detoxification of inflammatory reactive oxygen species through AppBCX allows E. coli to respire in an otherwise anaerobic environment.
Original language | English (US) |
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Pages (from-to) | 780-788.e5 |
Journal | Cell Host and Microbe |
Volume | 28 |
Issue number | 6 |
DOIs | |
State | Published - Dec 9 2020 |
Keywords
- cytochrome oxidase
- gut inflammation
- gut microbiota dysbiosis
- intestinal epithelium
- microbial respiration
- reactive oxygen species
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Virology