Epidemiology and surveillance for hepatocellular carcinoma: New trends

Amit G. Singal, Pietro Lampertico, Pierre Nahon

Research output: Contribution to journalReview articlepeer-review

499 Scopus citations


The burden of hepatocellular carcinoma (HCC) is highest in East Asia and Africa, although its incidence and mortality are rapidly rising in the United States and Europe. With the implementation of hepatitis B vaccination and hepatitis C treatment programmes worldwide, the epidemiology of HCC is shifting away from a disease predominated by viral hepatitis – an increasing proportion of cases are now attributable to non-alcoholic steatohepatitis. Surveillance using ultrasound, with or without alpha-fetoprotein, every 6 months has been associated with improved early detection and improved overall survival; however, limitations in implementation lead to a high proportion of HCC being detected at late stages in clinical practice. Herein, we review the current state of HCC surveillance and highlight areas for future research, including improved risk stratification of at-risk patients, surveillance tools with higher sensitivity and specificity for early HCC, and interventions to increase surveillance utilisation.

Original languageEnglish (US)
Pages (from-to)250-261
Number of pages12
JournalJournal of Hepatology
Issue number2
StatePublished - Feb 2020

ASJC Scopus subject areas

  • Hepatology


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