Eosinophilic Lung Disease

Jonathan C. Weissler

doi:10.1016/j.amjms.2017.03.020

Eosinophilic Lung Disease

Jonathan C. Weissler

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Eosinophils are involved in the pathogenesis of a number of lung diseases. Recent advances in eosinophil biology have now produced clinically applicable therapies that seek to counter eosinophilia in blood and lungs. This article reviews the basic biology of eosinophils and their role in mediating T-helper 2 cell responses. The current status of anticytokine therapy for eosinophilic lung disease is discussed. A clinical approach to eosinophilic lung disease based on symptoms and radiography is generated. The clinical significance of persistent eosinophilia in lung transplant patients and patients with asthma will receive special emphasis.

Original language	English (US)
Pages (from-to)	339-349
Number of pages	11
Journal	American Journal of the Medical Sciences
Volume	354
Issue number	4
DOIs	https://doi.org/10.1016/j.amjms.2017.03.020
State	Published - Oct 2017

Keywords

Asthma
Eosinophils
Hypereosinophilic syndrome
Interleukin 5
Lung allograft rejection

ASJC Scopus subject areas

Medicine(all)

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10.1016/j.amjms.2017.03.020

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title = "Eosinophilic Lung Disease",

abstract = "Eosinophils are involved in the pathogenesis of a number of lung diseases. Recent advances in eosinophil biology have now produced clinically applicable therapies that seek to counter eosinophilia in blood and lungs. This article reviews the basic biology of eosinophils and their role in mediating T-helper 2 cell responses. The current status of anticytokine therapy for eosinophilic lung disease is discussed. A clinical approach to eosinophilic lung disease based on symptoms and radiography is generated. The clinical significance of persistent eosinophilia in lung transplant patients and patients with asthma will receive special emphasis.",

keywords = "Asthma, Eosinophils, Hypereosinophilic syndrome, Interleukin 5, Lung allograft rejection",

author = "Weissler, {Jonathan C.}",

note = "Funding Information: This study was supported by a Grant from the Will Rogers Institute and the James M. Collins Center for Biomedical Research. Publisher Copyright: {\textcopyright} 2017 Southern Society for Clinical Investigation",

year = "2017",

month = oct,

doi = "10.1016/j.amjms.2017.03.020",

language = "English (US)",

volume = "354",

pages = "339--349",

journal = "The American journal of the medical sciences",

issn = "0002-9629",

publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Eosinophilic Lung Disease

AU - Weissler, Jonathan C.

N1 - Funding Information: This study was supported by a Grant from the Will Rogers Institute and the James M. Collins Center for Biomedical Research. Publisher Copyright: © 2017 Southern Society for Clinical Investigation

PY - 2017/10

Y1 - 2017/10

N2 - Eosinophils are involved in the pathogenesis of a number of lung diseases. Recent advances in eosinophil biology have now produced clinically applicable therapies that seek to counter eosinophilia in blood and lungs. This article reviews the basic biology of eosinophils and their role in mediating T-helper 2 cell responses. The current status of anticytokine therapy for eosinophilic lung disease is discussed. A clinical approach to eosinophilic lung disease based on symptoms and radiography is generated. The clinical significance of persistent eosinophilia in lung transplant patients and patients with asthma will receive special emphasis.

AB - Eosinophils are involved in the pathogenesis of a number of lung diseases. Recent advances in eosinophil biology have now produced clinically applicable therapies that seek to counter eosinophilia in blood and lungs. This article reviews the basic biology of eosinophils and their role in mediating T-helper 2 cell responses. The current status of anticytokine therapy for eosinophilic lung disease is discussed. A clinical approach to eosinophilic lung disease based on symptoms and radiography is generated. The clinical significance of persistent eosinophilia in lung transplant patients and patients with asthma will receive special emphasis.

KW - Asthma

KW - Eosinophils

KW - Hypereosinophilic syndrome

KW - Interleukin 5

KW - Lung allograft rejection

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U2 - 10.1016/j.amjms.2017.03.020

DO - 10.1016/j.amjms.2017.03.020

M3 - Review article

C2 - 29078837

AN - SCOPUS:85032658173

SN - 0002-9629

VL - 354

SP - 339

EP - 349

JO - The American journal of the medical sciences

JF - The American journal of the medical sciences

IS - 4

ER -

Eosinophilic Lung Disease

Abstract

Keywords

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