Eosinophilic esophagitis: novel concepts regarding pathogenesis and clinical manifestations

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


This report explores two hypotheses regarding eosinophilic esophagitis (EoE): (1) that the use of proton pump inhibitors (PPIs) might contribute to the pathogenesis of EoE by preventing peptic digestion of food allergens, by increasing gastric mucosal permeability to enable gastric absorption of those undegraded food allergens, and by causing microbial dysbiosis, and (2) that EoE, like eosinophilic gastroenteritis, might have mucosal-predominant and muscle-predominant forms, and that the muscle-predominant form of EoE might cause a variety of esophageal motility disorders including achalasia.

Original languageEnglish (US)
Pages (from-to)837-844
Number of pages8
JournalJournal of Gastroenterology
Issue number10
StatePublished - Oct 1 2019
Externally publishedYes


  • Achalasia
  • Esophageal motility
  • Proton pump inhibitors

ASJC Scopus subject areas

  • Gastroenterology


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