Eosinophilic esophagitis: Interactions with gastroesophageal reflux disease

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36 Scopus citations


Gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) are not mutually exclusive. The notion that GERD and EoE can be distinguished by the response to proton pump inhibitor (PPI) treatment is based on the mistaken assumption that gastric acid suppression is the only important therapeutic effect of PPIs, and therefore only GERD can respond to PPIs. We believe that a clinical or histologic response to PPIs does not rule in GERD or rule out EoE. We recommend a trial of PPI therapy for patients with symptomatic esophageal eosinophilia, even if the diagnosis of EoE seems clear-cut.

Original languageEnglish (US)
Pages (from-to)243-256
Number of pages14
JournalGastroenterology Clinics of North America
Issue number2
StatePublished - Jun 2014


  • Eosinophilic esophagitis
  • Gastroesophageal reflux disease
  • PPI-responsive esophageal eosinophilia
  • Proton pump inhibitors

ASJC Scopus subject areas

  • Gastroenterology


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