Enhancer RNAs: A class of long noncoding RNAs synthesized at enhancers

Tae Kyung Kim, Martin Hemberg, Jesse M. Gray

Research output: Contribution to journalArticlepeer-review

126 Scopus citations


Recent studies have revealed that active enhancers are transcribed, producing a class of noncoding RNAs called enhancer RNAs (eRNAs). eRNAs are distinct from long noncoding RNAs (lncRNAs), but these two species of noncoding RNAs may share a similar role in the activation of mRNA transcription. Emerging studies, showing that eRNAs function in controlling mRNA transcription, challenge the idea that enhancers are merely sites of transcription factor assembly. Instead, communicationbetween promoters andenhancers canbebidirectional with promoters required to activate enhancer transcription. Reciprocally, eRNAs may then facilitate enhancer–promoter interaction or activate promoter-driven transcription.

Original languageEnglish (US)
Article numbera018622
JournalCold Spring Harbor Perspectives in Biology
Issue number1
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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