'Engineering' the wound-healing process: The association of chitosan- mediated inhibition of wound-model contraction with inhibition of gap junctions

Muthumarthanda R. Mariappan; John G. Williams; Morton D. Prager; Robert C. Eberhart

doi:10.1109/51.805140

'Engineering' the wound-healing process: The association of chitosan- mediated inhibition of wound-model contraction with inhibition of gap junctions

Muthumarthanda R. Mariappan, John G. Williams, Morton D. Prager, Robert C. Eberhart

Surgery

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The final stage in dermal wound healing following burn or trauma involves remodeling the granulation tissue. This stage also takes into account the possibility of wound contraction. Functional disregulation of wound contraction occurs in fibrotic diseases such as pathological contractures and scar formation. Controlling fibroblast transformation may enable useful engineering of the wound contraction response. The effects of various wound-healing agents on fibroblast behavior was studied. The study hypothesizes that the efficient contraction of the in vitro wound model is associated with gap junction formation between cells, and conversely, that inhibition of the in vitro wound-model contraction is associated with inhibition of GJ between cells.

Original language	English (US)
Pages (from-to)	22-26
Number of pages	5
Journal	IEEE Engineering in Medicine and Biology Magazine
Volume	18
Issue number	6
DOIs	https://doi.org/10.1109/51.805140
State	Published - Nov 1999

ASJC Scopus subject areas

Biomedical Engineering

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10.1109/51.805140

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'Engineering' the wound-healing process: The association of chitosan- mediated inhibition of wound-model contraction with inhibition of gap junctions. / Mariappan, Muthumarthanda R.; Williams, John G.; Prager, Morton D. et al.
In: IEEE Engineering in Medicine and Biology Magazine, Vol. 18, No. 6, 11.1999, p. 22-26.

Research output: Contribution to journal › Article › peer-review

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abstract = "The final stage in dermal wound healing following burn or trauma involves remodeling the granulation tissue. This stage also takes into account the possibility of wound contraction. Functional disregulation of wound contraction occurs in fibrotic diseases such as pathological contractures and scar formation. Controlling fibroblast transformation may enable useful engineering of the wound contraction response. The effects of various wound-healing agents on fibroblast behavior was studied. The study hypothesizes that the efficient contraction of the in vitro wound model is associated with gap junction formation between cells, and conversely, that inhibition of the in vitro wound-model contraction is associated with inhibition of GJ between cells.",

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'Engineering' the wound-healing process: The association of chitosan- mediated inhibition of wound-model contraction with inhibition of gap junctions

Abstract

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