Endothelin-secreting tumor

K. Yokokawa, H. Tahara, M. Kohno, K. Murakawa -i., K. Yasunari, K. Nakagawa, T. Hamada, S. Otani, M. Yanagisawa, T. Takeda

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Recently, we have reported two eases with endothelin (ET)-secreting tumor presenting with hypertension and elevated plasma endothelin-1 (ET-1) levels. The present study examines the histopathology of the ET-secreting tumor in one of these cases. The neoplasm was located in the skin and microscopically characterized as a malignant hemangioendothelioma by remarkable intra-vascular proliferations of atypical endothelium with the expression of Factor VIII-related antigen in the tumor cells. The tumor enlarged rapidly with rising ET-1 and blood pressure levels. The ET-1 content and its messenger RNA expression in the tumor extract were higher than those from normal parts of skin. ET-1 may play a pathophysiological role in patients with ET-secreting malignant hemangioendothelioma.

Original languageEnglish (US)
Pages (from-to)S398-S41
JournalJournal of Cardiovascular Pharmacology
StatePublished - 1991


  • Endothelin-1
  • Endothelin-1 mRNA
  • Histopathology
  • Hypertension
  • Malignant hemangioendothelioma
  • Skin

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine


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