Abstract
Recently, we have reported two eases with endothelin (ET)-secreting tumor presenting with hypertension and elevated plasma endothelin-1 (ET-1) levels. The present study examines the histopathology of the ET-secreting tumor in one of these cases. The neoplasm was located in the skin and microscopically characterized as a malignant hemangioendothelioma by remarkable intra-vascular proliferations of atypical endothelium with the expression of Factor VIII-related antigen in the tumor cells. The tumor enlarged rapidly with rising ET-1 and blood pressure levels. The ET-1 content and its messenger RNA expression in the tumor extract were higher than those from normal parts of skin. ET-1 may play a pathophysiological role in patients with ET-secreting malignant hemangioendothelioma.
Original language | English (US) |
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Pages (from-to) | S398-S41 |
Journal | Journal of Cardiovascular Pharmacology |
Volume | 17 |
DOIs | |
State | Published - 1991 |
Keywords
- Endothelin-1
- Endothelin-1 mRNA
- Histopathology
- Hypertension
- Malignant hemangioendothelioma
- Skin
ASJC Scopus subject areas
- Pharmacology
- Cardiology and Cardiovascular Medicine