Endothelin: A novel peptide in the posterior pituitary system

Toshihiro Yoshizawa, Osamu Shinmi, Adel Giaid, Masashi Yanagisawa, Sally J. Gibson, Sadao Kimura, Yasuo Uchiyama, Julia M. Polak, Tomoh Masaki, Ichiro Kanazawa

Research output: Contribution to journalArticlepeer-review

303 Scopus citations


Endothelin (ET), originally characterized as a 21-residue vasoconstrictor peptide from endothelial cells, is present in the porcine spinal cord and may act as a neuropeptide. Endothelin-like immunoreactivity has now been demonstrated by immunohistochemistry in the paraventricular and supraoptic nuclear neurons and their terminals in the posterior pituitary of the pig and the rat. The presence of ET in the porcine hypothalamus was confirmed by reversed-phase high-pressure liquid chromatography and radioimmunoassay. Moreover, in situ hybridization demonstrated ET messenger RNA in porcine paraventricular nuclear neurons. Endothelin-like immunoreactive products in the posterior pituitary of the rat were depleted by water deprivation, suggesting a release of ET under physiological conditions. These findings indicate that ET is synthesized in the posterior pituitary system and may be involved in neurosecretory functions.

Original languageEnglish (US)
Pages (from-to)462-464
Number of pages3
Issue number4941
StatePublished - 1990

ASJC Scopus subject areas

  • General


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