Endothelial function as a therapeutic target in coronary artery disease.

N. Sharma, T. C. Andrews

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


In healthy individuals, endothelial cells regulate a host of functions including vasomotor tone, thrombosis/ fibrinolysis, and cell-cell interactions. The development of endothelial dysfunction may be a common pathway by which cardiovascular risk factors impact plaque formation, growth, and rupture. Many pharmacologic and nonpharmacologic interventions known to decrease cardiovascular risk also improve endothelial function. For these reasons, some have suggested that improvement in endothelial function may be an important therapeutic target in the treatment of coronary artery disease.

Original languageEnglish (US)
Pages (from-to)303-307
Number of pages5
JournalCurrent atherosclerosis reports
Issue number4
StatePublished - Jul 2000

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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