Endothelial cell studies in patients after photorefractive keratectomy for hyperopia

Nada S. Jabbur; Michael W. Belin; Robert W Bowman; Richard E. Braunstein; Harrison D Cavanagh; David H. Haight; Kenneth Kenyon; Colman Kraff; Manus C. Kraff; James C. Liu; Ezra Maguen; Eric Mandel; Robert J. Masi; James P McCulley; Anthony Nesburn; Terrence P. O'Brien; Yaron Rabinowitz; Peter Rapoza; Robert Schultze; James J. Salz; Jonathan Talamo; Mark Volpicelli; Robert M. Webb; Marc G. Odrich; Kenneth A. Greenberg; Jerome A. Legerton; David M. Patino; Kitty Legerton; Kris Gambelin; Anais Laborde; Berni DeFrenchi

Endothelial cell studies in patients after photorefractive keratectomy for hyperopia

Nada S. Jabbur, Michael W. Belin, Robert W Bowman, Richard E. Braunstein, Harrison D Cavanagh, David H. Haight, Kenneth Kenyon, Colman Kraff, Manus C. Kraff, James C. Liu, Ezra Maguen, Eric Mandel, Robert J. Masi, James P McCulley, Anthony Nesburn, Terrence P. O'Brien, Yaron Rabinowitz, Peter Rapoza, Robert Schultze, James J. SalzJonathan Talamo, Mark Volpicelli, Robert M. Webb, Marc G. Odrich, Kenneth A. Greenberg, Jerome A. Legerton, David M. Patino, Kitty Legerton, Kris Gambelin, Anais Laborde, Berni DeFrenchi

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12 Scopus citations

Abstract

PURPOSE: To report central and peripheral corneal endothelial cell studies performed as part of the VISX hyperopic photorefractive keratectomy (PRK) clinical trial. METHODS: During this prospective, multicenter clinical trial, which was part of an FDA investigation, endothelial cell specular microscopy was done at five centers. Non-contact central and peripheral cell density, percent hexagonality, and coefficient of variability of cell size were obtained using the Konan Noncon Robo SP-8000FA with BAMBI analysis software. Data were gathered at baseline and at 1, 6, and 12 months after hyperopic PRK. RESULTS: Analysis of results of 171 eyes demonstrated no statistically significant detrimental changes in the corneal endothelium at any postoperative time point. The statistically significant changes noted were interpreted as an improvement in cell morphology and were attributed to the cessation of contact lens wear following treatment. CONCLUSION: Hyperopic PRK with the VISX STAR S2 Excimer Laser System produced no statistically significant adverse effect on the corneal endothelium.

Original language	English (US)
Pages (from-to)	142-148
Number of pages	7
Journal	Journal of Refractive Surgery
Volume	19
Issue number	2
State	Published - Mar 2003

ASJC Scopus subject areas

Surgery
Ophthalmology

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Jabbur, N. S., Belin, M. W., Bowman, R. W., Braunstein, R. E., Cavanagh, H. D., Haight, D. H., Kenyon, K., Kraff, C., Kraff, M. C., Liu, J. C., Maguen, E., Mandel, E., Masi, R. J., McCulley, J. P., Nesburn, A., O'Brien, T. P., Rabinowitz, Y., Rapoza, P., Schultze, R., ... DeFrenchi, B. (2003). Endothelial cell studies in patients after photorefractive keratectomy for hyperopia. Journal of Refractive Surgery, 19(2), 142-148.

Jabbur, NS, Belin, MW, Bowman, RW, Braunstein, RE, Cavanagh, HD, Haight, DH, Kenyon, K, Kraff, C, Kraff, MC, Liu, JC, Maguen, E, Mandel, E, Masi, RJ, McCulley, JP, Nesburn, A, O'Brien, TP, Rabinowitz, Y, Rapoza, P, Schultze, R, Salz, JJ, Talamo, J, Volpicelli, M, Webb, RM, Odrich, MG, Greenberg, KA, Legerton, JA, Patino, DM, Legerton, K, Gambelin, K, Laborde, A & DeFrenchi, B 2003, 'Endothelial cell studies in patients after photorefractive keratectomy for hyperopia', Journal of Refractive Surgery, vol. 19, no. 2, pp. 142-148.

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title = "Endothelial cell studies in patients after photorefractive keratectomy for hyperopia",

abstract = "PURPOSE: To report central and peripheral corneal endothelial cell studies performed as part of the VISX hyperopic photorefractive keratectomy (PRK) clinical trial. METHODS: During this prospective, multicenter clinical trial, which was part of an FDA investigation, endothelial cell specular microscopy was done at five centers. Non-contact central and peripheral cell density, percent hexagonality, and coefficient of variability of cell size were obtained using the Konan Noncon Robo SP-8000FA with BAMBI analysis software. Data were gathered at baseline and at 1, 6, and 12 months after hyperopic PRK. RESULTS: Analysis of results of 171 eyes demonstrated no statistically significant detrimental changes in the corneal endothelium at any postoperative time point. The statistically significant changes noted were interpreted as an improvement in cell morphology and were attributed to the cessation of contact lens wear following treatment. CONCLUSION: Hyperopic PRK with the VISX STAR S2 Excimer Laser System produced no statistically significant adverse effect on the corneal endothelium.",

author = "Jabbur, {Nada S.} and Belin, {Michael W.} and Bowman, {Robert W} and Braunstein, {Richard E.} and Cavanagh, {Harrison D} and Haight, {David H.} and Kenneth Kenyon and Colman Kraff and Kraff, {Manus C.} and Liu, {James C.} and Ezra Maguen and Eric Mandel and Masi, {Robert J.} and McCulley, {James P} and Anthony Nesburn and O'Brien, {Terrence P.} and Yaron Rabinowitz and Peter Rapoza and Robert Schultze and Salz, {James J.} and Jonathan Talamo and Mark Volpicelli and Webb, {Robert M.} and Odrich, {Marc G.} and Greenberg, {Kenneth A.} and Legerton, {Jerome A.} and Patino, {David M.} and Kitty Legerton and Kris Gambelin and Anais Laborde and Berni DeFrenchi",

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AU - Jabbur, Nada S.

AU - Belin, Michael W.

AU - Bowman, Robert W

AU - Braunstein, Richard E.

AU - Cavanagh, Harrison D

AU - Haight, David H.

AU - Kenyon, Kenneth

AU - Kraff, Colman

AU - Kraff, Manus C.

AU - Liu, James C.

AU - Maguen, Ezra

AU - Mandel, Eric

AU - Masi, Robert J.

AU - McCulley, James P

AU - Nesburn, Anthony

AU - O'Brien, Terrence P.

AU - Rabinowitz, Yaron

AU - Rapoza, Peter

AU - Schultze, Robert

AU - Salz, James J.

AU - Talamo, Jonathan

AU - Volpicelli, Mark

AU - Webb, Robert M.

AU - Odrich, Marc G.

AU - Greenberg, Kenneth A.

AU - Legerton, Jerome A.

AU - Patino, David M.

AU - Legerton, Kitty

AU - Gambelin, Kris

AU - Laborde, Anais

AU - DeFrenchi, Berni

PY - 2003/3

Y1 - 2003/3

N2 - PURPOSE: To report central and peripheral corneal endothelial cell studies performed as part of the VISX hyperopic photorefractive keratectomy (PRK) clinical trial. METHODS: During this prospective, multicenter clinical trial, which was part of an FDA investigation, endothelial cell specular microscopy was done at five centers. Non-contact central and peripheral cell density, percent hexagonality, and coefficient of variability of cell size were obtained using the Konan Noncon Robo SP-8000FA with BAMBI analysis software. Data were gathered at baseline and at 1, 6, and 12 months after hyperopic PRK. RESULTS: Analysis of results of 171 eyes demonstrated no statistically significant detrimental changes in the corneal endothelium at any postoperative time point. The statistically significant changes noted were interpreted as an improvement in cell morphology and were attributed to the cessation of contact lens wear following treatment. CONCLUSION: Hyperopic PRK with the VISX STAR S2 Excimer Laser System produced no statistically significant adverse effect on the corneal endothelium.

AB - PURPOSE: To report central and peripheral corneal endothelial cell studies performed as part of the VISX hyperopic photorefractive keratectomy (PRK) clinical trial. METHODS: During this prospective, multicenter clinical trial, which was part of an FDA investigation, endothelial cell specular microscopy was done at five centers. Non-contact central and peripheral cell density, percent hexagonality, and coefficient of variability of cell size were obtained using the Konan Noncon Robo SP-8000FA with BAMBI analysis software. Data were gathered at baseline and at 1, 6, and 12 months after hyperopic PRK. RESULTS: Analysis of results of 171 eyes demonstrated no statistically significant detrimental changes in the corneal endothelium at any postoperative time point. The statistically significant changes noted were interpreted as an improvement in cell morphology and were attributed to the cessation of contact lens wear following treatment. CONCLUSION: Hyperopic PRK with the VISX STAR S2 Excimer Laser System produced no statistically significant adverse effect on the corneal endothelium.

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Endothelial cell studies in patients after photorefractive keratectomy for hyperopia

Abstract

ASJC Scopus subject areas

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