Endothelial cell studies in patients after photorefractive keratectomy for hyperopia

Nada S. Jabbur, Michael W. Belin, Robert W Bowman, Richard E. Braunstein, Harrison D Cavanagh, David H. Haight, Kenneth Kenyon, Colman Kraff, Manus C. Kraff, James C. Liu, Ezra Maguen, Eric Mandel, Robert J. Masi, James P McCulley, Anthony Nesburn, Terrence P. O'Brien, Yaron Rabinowitz, Peter Rapoza, Robert Schultze, James J. SalzJonathan Talamo, Mark Volpicelli, Robert M. Webb, Marc G. Odrich, Kenneth A. Greenberg, Jerome A. Legerton, David M. Patino, Kitty Legerton, Kris Gambelin, Anais Laborde, Berni DeFrenchi

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


PURPOSE: To report central and peripheral corneal endothelial cell studies performed as part of the VISX hyperopic photorefractive keratectomy (PRK) clinical trial. METHODS: During this prospective, multicenter clinical trial, which was part of an FDA investigation, endothelial cell specular microscopy was done at five centers. Non-contact central and peripheral cell density, percent hexagonality, and coefficient of variability of cell size were obtained using the Konan Noncon Robo SP-8000FA with BAMBI analysis software. Data were gathered at baseline and at 1, 6, and 12 months after hyperopic PRK. RESULTS: Analysis of results of 171 eyes demonstrated no statistically significant detrimental changes in the corneal endothelium at any postoperative time point. The statistically significant changes noted were interpreted as an improvement in cell morphology and were attributed to the cessation of contact lens wear following treatment. CONCLUSION: Hyperopic PRK with the VISX STAR S2 Excimer Laser System produced no statistically significant adverse effect on the corneal endothelium.

Original languageEnglish (US)
Pages (from-to)142-148
Number of pages7
JournalJournal of Refractive Surgery
Issue number2
StatePublished - Mar 2003

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology


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