Endometrial stromal tumors: Diagnostic updates and challenges

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6 Scopus citations


Endometrial stromal tumors are rare uterine mesenchymal tumors of endometrial stromal origin. They are classified into endometrial stromal nodule, low-grade endometrial stromal sarcoma, high-grade endometrial stromal sarcoma, and undifferentiated uterine sarcoma by the current (2020) WHO classification. Correct diagnosis of endometrial stromal tumors is critical for proper patient management. However, due to infrequent encounters, overlapping morphological features and immunohistochemical profiles, the differential diagnoses among endometrial stromal lesions and their morphologic mimics are often challenging. Partially with our own experience, here we review and summarize the tumor morphology, immunohistochemical phenotype, as well as molecular feature of endometrial stromal tumors and key differential diagnoses, emphasizing the newest developments and their utilization in daily practice.

Original languageEnglish (US)
Pages (from-to)201-212
Number of pages12
JournalSeminars in Diagnostic Pathology
Issue number3
StatePublished - May 2022


  • Endometrial sarcoma
  • Endometrial stromal sarcoma
  • Endometrial stromal tumor
  • Immunophenotype

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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