Emergency Medicine Management of Sickle Cell Disease Complications: An Evidence-Based Update

Erica Simon, Brit Long, Alex Koyfman

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background Sickle cell disease (SCD) affects approximately 100,000 individuals in the United States. Due to alterations in the structural conformation of hemoglobin molecules under deoxygenated conditions, patients with SCD are predisposed to numerous sequelae, many of which require acute intervention. Objective Our aim was to provide emergency physicians with an evidence-based update regarding the diagnosis and management of SCD complications. Discussion SCD patients experience significant morbidity and mortality secondary to cerebrovascular accident, acute chest syndrome, acute vaso-occlusive pain crises, SCD-related multi-organ failure, cholecystitis, acute intrahepatic cholestasis, acute sickle hepatic crisis, acute hepatic sequestration, priapism, and renal disease. Emergency physicians must recognize acute manifestations of SCD in order to deliver timely management and determine patient disposition. Conclusions A comprehensive review of the emergency department management of acute SCD complications is provided. Comprehensive understanding of these aspects of SCD can assist physicians in expediting patient evaluation and treatment, thus decreasing the morbidity and mortality associated with this hemoglobinopathy.

Original languageEnglish (US)
Pages (from-to)370-381
Number of pages12
JournalJournal of Emergency Medicine
Issue number4
StatePublished - Oct 1 2016


  • acute chest
  • acute pain crisis
  • cerebrovascular accident
  • sickle cell disease
  • transfusion

ASJC Scopus subject areas

  • Emergency Medicine


Dive into the research topics of 'Emergency Medicine Management of Sickle Cell Disease Complications: An Evidence-Based Update'. Together they form a unique fingerprint.

Cite this